A conceptual framework for astrocyte function

C Murphy-Royal, SN Ching, T Papouin - Nature neuroscience, 2023 - nature.com
The participation of astrocytes in brain computation was hypothesized in 1992, coinciding
with the discovery that these cells display a form of intracellular Ca2+ signaling sensitive to …

Why is everyone talking about brain state?

AS Greene, C Horien, D Barson, D Scheinost… - Trends in …, 2023 - cell.com
The rapid and coordinated propagation of neural activity across the brain provides the
foundation for complex behavior and cognition. Technical advances across neuroscience …

In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline

HIL Jacobs, JA Becker, K Kwong… - Science translational …, 2021 - science.org
Several autopsy studies recognize the locus coeruleus (LC) as the initial site of
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU …

Locus coeruleus: a new look at the blue spot

GR Poe, S Foote, O Eschenko, JP Johansen… - Nature Reviews …, 2020 - nature.com
The locus coeruleus (LC), or 'blue spot', is a small nucleus located deep in the brainstem
that provides the far-reaching noradrenergic neurotransmitter system of the brain. This …

Fast-specific fluorescent probes to visualize norepinephrine signaling pathways and its flux in the epileptic mice brain

H Yan, Y Wang, F Huo, C Yin - Journal of the American Chemical …, 2023 - ACS Publications
Norepinephrine (NE) is synthesized in the locus coeruleus and widely projected throughout
the brain and spinal cord. It regulates various actions and consciousness linked to a variety …

Mechanisms of memory under stress

L Schwabe, EJ Hermans, M Joëls, B Roozendaal - Neuron, 2022 - cell.com
It is well established that stress has a major impact on memory, driven by the concerted
action of various stress mediators on the brain. Recent years, however, have seen …

Functional brain networks reflect spatial and temporal autocorrelation

M Shinn, A Hu, L Turner, S Noble, KH Preller, JL Ji… - Nature …, 2023 - nature.com
High-throughput experimental methods in neuroscience have led to an explosion of
techniques for measuring complex interactions and multi-dimensional patterns. However …

Questions and controversies in the study of time-varying functional connectivity in resting fMRI

DJ Lurie, D Kessler, DS Bassett, RF Betzel… - Network …, 2020 - direct.mit.edu
The brain is a complex, multiscale dynamical system composed of many interacting regions.
Knowledge of the spatiotemporal organization of these interactions is critical for establishing …

The role of the salience network in cognitive and affective deficits

J Schimmelpfennig, J Topczewski… - Frontiers in human …, 2023 - frontiersin.org
Analysis and interpretation of studies on cognitive and affective dysregulation often draw
upon the network paradigm, especially the Triple Network Model, which consists of the …

Computational models link cellular mechanisms of neuromodulation to large-scale neural dynamics

JM Shine, EJ Müller, B Munn, J Cabral, RJ Moran… - Nature …, 2021 - nature.com
Decades of neurobiological research have disclosed the diverse manners in which the
response properties of neurons are dynamically modulated to support adaptive cognitive …