Comprehensive review in current developments of imidazole‐based medicinal chemistry
L Zhang, XM Peng, GLV Damu… - Medicinal research …, 2014 - Wiley Online Library
Imidazole ring is an important five‐membered aromatic heterocycle widely present in natural
products and synthetic molecules. The unique structural feature of imidazole ring with …
products and synthetic molecules. The unique structural feature of imidazole ring with …
Recent progress in the discovery of next generation inhibitors of aromatase from the structure–function perspective
Human aromatase catalyzes the synthesis of estrogen from androgen with high substrate
specificity. For the past 40 years, aromatase has been a target of intense inhibitor discovery …
specificity. For the past 40 years, aromatase has been a target of intense inhibitor discovery …
Combating breast cancer with non-steroidal aromatase inhibitors (NSAIs): Understanding the chemico-biological interactions through comparative SAR/QSAR study
It is a challenging task to design target-specific and less toxic non-steroidal aromatase
inhibitors (NSAIs) though the modeling studies for designing anti-aromatase molecules have …
inhibitors (NSAIs) though the modeling studies for designing anti-aromatase molecules have …
Synthesis and molecular docking of 1, 2, 3-triazole-based sulfonamides as aromatase inhibitors
R Pingaew, V Prachayasittikul, P Mandi… - Bioorganic & medicinal …, 2015 - Elsevier
Abstract A series of 1, 4-disubstituted-1, 2, 3-triazoles (13–35) containing sulfonamide
moiety were synthesized and evaluated for their aromatase inhibitory effects. Most triazoles …
moiety were synthesized and evaluated for their aromatase inhibitory effects. Most triazoles …
Dietary flavones as dual inhibitors of DNA methyltransferases and histone methyltransferases
Methylation of DNA and histone proteins are mutually involved in the epigenetic regulation
of gene expression mediated by DNA methyltransferases (DNMTs) and histone …
of gene expression mediated by DNA methyltransferases (DNMTs) and histone …
SAR, QSAR and docking of anticancer flavonoids and variants: a review
L Scotti… - Current topics in …, 2012 - ingentaconnect.com
Flavonoids are phenolic compounds, secondary metabolites of plants that cause several
benefits to our health, including helping the treatment against cancer. These …
benefits to our health, including helping the treatment against cancer. These …
Large-scale QSAR study of aromatase inhibitors using SMILES-based descriptors
A Worachartcheewan, P Mandi… - Chemometrics and …, 2014 - Elsevier
Aromatase inhibitors (AIs) represent a promising therapeutic class of anticancer agents
against estrogen receptor-positive breast cancer. Bioactivity data on pIC 50 of 973 AIs were …
against estrogen receptor-positive breast cancer. Bioactivity data on pIC 50 of 973 AIs were …
Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl) thiazole derivatives
Steroidal and non-steroidal aromatase inhibitors target the suppression of estrogen
biosynthesis in the treatment of breast cancer. Researchers have increasingly focused on …
biosynthesis in the treatment of breast cancer. Researchers have increasingly focused on …
[HTML][HTML] Towards understanding aromatase inhibitory activity via QSAR modeling
W Shoombuatong, N Schaduangrat… - EXCLI …, 2018 - ncbi.nlm.nih.gov
Aromatase is a rate-limiting enzyme for estrogen biosynthesis that is overproduced in breast
cancer tissue. To block the growth of breast tumors, aromatase inhibitors (AIs) are employed …
cancer tissue. To block the growth of breast tumors, aromatase inhibitors (AIs) are employed …
Dual binding site and selective acetylcholinesterase inhibitors derived from integrated pharmacophore models and sequential virtual screening
S Gupta, CG Mohan - BioMed Research International, 2014 - Wiley Online Library
In this study, we have employed in silico methodology combining double pharmacophore
based screening, molecular docking, and ADME/T filtering to identify dual binding site …
based screening, molecular docking, and ADME/T filtering to identify dual binding site …