Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms
Abstract The Enhanced Permeability and Retention (EPR) effect has been recognized as the
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …
Stem cell-based bone and dental regeneration: a view of microenvironmental modulation
C Zheng, J Chen, S Liu, Y Jin - International Journal of Oral Science, 2019 - nature.com
In modern medicine, bone and dental loss and defects are common and widespread
morbidities, for which regenerative therapy has shown great promise. Mesenchymal stem …
morbidities, for which regenerative therapy has shown great promise. Mesenchymal stem …
Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells
J Leibacher, R Henschler - Stem cell research & therapy, 2016 - Springer
Mesenchymal stem/stromal cells (MSCs) are increasingly used as an intravenously applied
cellular therapeutic. They were found to be potent in situations such as tissue repair or …
cellular therapeutic. They were found to be potent in situations such as tissue repair or …
Trophic effects of mesenchymal stem cells in tissue regeneration
Mesenchymal stem cells (MSCs) are considered to hold great therapeutic value for cell-
based therapy and for tissue regeneration in particular. Recent evidence indicates that the …
based therapy and for tissue regeneration in particular. Recent evidence indicates that the …
Mesenchymal stem cells
Stem cells have two features: the ability to differentiate along different lineages and the
ability of self-renewal. Two major types of stem cells have been described, namely …
ability of self-renewal. Two major types of stem cells have been described, namely …
Effects of oxidative stress on mesenchymal stem cell biology
RA Denu, P Hematti - Oxidative medicine and cellular longevity, 2016 - Wiley Online Library
Mesenchymal stromal/stem cells (MSCs) are multipotent stem cells present in most fetal and
adult tissues. Ex vivo culture‐expanded MSCs are being investigated for tissue repair and …
adult tissues. Ex vivo culture‐expanded MSCs are being investigated for tissue repair and …
Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing
G Chamberlain, J Fox, B Ashton, J Middleton - Stem cells, 2007 - academic.oup.com
MSCs are nonhematopoietic stromal cells that are capable of differentiating into, and
contribute to the regeneration of, mesenchymal tissues such as bone, cartilage, muscle …
contribute to the regeneration of, mesenchymal tissues such as bone, cartilage, muscle …
[HTML][HTML] Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
A Bartholomew, C Sturgeon, M Siatskas, K Ferrer… - Experimental …, 2002 - Elsevier
OBJECTIVE: Mesenchymal stem cells (MSCs), multipotential cells that reside within the
bone marrow, can be induced to differentiate into various components of the marrow …
bone marrow, can be induced to differentiate into various components of the marrow …
[HTML][HTML] Mesenchymal stem cell homing: the devil is in the details
The study of MSC trafficking is clinically relevant for minimally invasive cell therapy to
promote regeneration of damaged tissue, to treat inflammation, and to promote …
promote regeneration of damaged tissue, to treat inflammation, and to promote …
Adult mesenchymal stem cells for tissue engineering versus regenerative medicine
AI Caplan - Journal of cellular physiology, 2007 - Wiley Online Library
Adult mesenchymal stem cells (MSCs) can be isolated from bone marrow or marrow
aspirates and because they are culture‐dish adherent, they can be expanded in culture …
aspirates and because they are culture‐dish adherent, they can be expanded in culture …