Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms

Y Zi, K Yang, J He, Z Wu, J Liu, W Zhang - Advanced Drug Delivery …, 2022 - Elsevier
Abstract The Enhanced Permeability and Retention (EPR) effect has been recognized as the
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …

Stem cell-based bone and dental regeneration: a view of microenvironmental modulation

C Zheng, J Chen, S Liu, Y Jin - International Journal of Oral Science, 2019 - nature.com
In modern medicine, bone and dental loss and defects are common and widespread
morbidities, for which regenerative therapy has shown great promise. Mesenchymal stem …

Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells

J Leibacher, R Henschler - Stem cell research & therapy, 2016 - Springer
Mesenchymal stem/stromal cells (MSCs) are increasingly used as an intravenously applied
cellular therapeutic. They were found to be potent in situations such as tissue repair or …

Trophic effects of mesenchymal stem cells in tissue regeneration

Y Fu, L Karbaat, L Wu, J Leijten, SK Both… - … Engineering Part B …, 2017 - liebertpub.com
Mesenchymal stem cells (MSCs) are considered to hold great therapeutic value for cell-
based therapy and for tissue regeneration in particular. Recent evidence indicates that the …

Mesenchymal stem cells

DC Ding, WC Shyu, SZ Lin - Cell transplantation, 2011 - journals.sagepub.com
Stem cells have two features: the ability to differentiate along different lineages and the
ability of self-renewal. Two major types of stem cells have been described, namely …

Effects of oxidative stress on mesenchymal stem cell biology

RA Denu, P Hematti - Oxidative medicine and cellular longevity, 2016 - Wiley Online Library
Mesenchymal stromal/stem cells (MSCs) are multipotent stem cells present in most fetal and
adult tissues. Ex vivo culture‐expanded MSCs are being investigated for tissue repair and …

Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing

G Chamberlain, J Fox, B Ashton, J Middleton - Stem cells, 2007 - academic.oup.com
MSCs are nonhematopoietic stromal cells that are capable of differentiating into, and
contribute to the regeneration of, mesenchymal tissues such as bone, cartilage, muscle …

[HTML][HTML] Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo

A Bartholomew, C Sturgeon, M Siatskas, K Ferrer… - Experimental …, 2002 - Elsevier
OBJECTIVE: Mesenchymal stem cells (MSCs), multipotential cells that reside within the
bone marrow, can be induced to differentiate into various components of the marrow …

[HTML][HTML] Mesenchymal stem cell homing: the devil is in the details

JM Karp, GSL Teo - Cell stem cell, 2009 - cell.com
The study of MSC trafficking is clinically relevant for minimally invasive cell therapy to
promote regeneration of damaged tissue, to treat inflammation, and to promote …

Adult mesenchymal stem cells for tissue engineering versus regenerative medicine

AI Caplan - Journal of cellular physiology, 2007 - Wiley Online Library
Adult mesenchymal stem cells (MSCs) can be isolated from bone marrow or marrow
aspirates and because they are culture‐dish adherent, they can be expanded in culture …