The extended granin family: structure, function, and biomedical implications

A Bartolomucci, R Possenti, SK Mahata… - Endocrine …, 2011 - academic.oup.com
The chromogranins (chromogranin A and chromogranin B), secretogranins (secretogranin II
and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) …

Chromogranin A: from laboratory to clinical aspects of patients with neuroendocrine tumors

P Di Giacinto, F Rota, L Rizza… - International Journal …, 2018 - Wiley Online Library
Background. Neuroendocrine tumors (NETs) are characterized by having behavior and
prognosis that depend upon tumor histology, primary site, staging, and proliferative index …

GC content shapes mRNA storage and decay in human cells

M Courel, Y Clément, C Bossevain, D Foretek… - Elife, 2019 - elifesciences.org
mRNA translation and decay appear often intimately linked although the rules of this
interplay are poorly understood. In this study, we combined our recent P-body transcriptome …

Chromogranins A and B and secretogranin II: evolutionary and functional aspects

M Montero‐Hadjadje, S Vaingankar, S Elias… - Acta …, 2008 - Wiley Online Library
Chromogranins/secretogranins or granins are a class of acidic, secretory proteins that occur
in endocrine, neuroendocrine, and neuronal cells. Granins are the precursors of several …

The crucial role of chromogranins in storage and exocytosis revealed using chromaffin cells from chromogranin A null mouse

MS Montesinos, JD Machado, M Camacho… - Journal of …, 2008 - Soc Neuroscience
Chromogranins (Cgs) are the major soluble proteins of dense-core secretory vesicles.
Chromaffin cells from Chga null mice [chromogranin A knock-out (CgA-KO)] exhibited∼ …

Chromogranin A in the laboratory diagnosis of pheochromocytoma and paraganglioma

R Bílek, P Vlček, L Šafařík, D Michalský, K Novák… - Cancers, 2019 - mdpi.com
This work discusses the clinical performance of chromogranin A (CGA), a commonly
measured marker in neuroendocrine neoplasms, for the diagnosis of pheochromocytoma …

The chromaffin vesicle: advances in understanding the composition of a versatile, multifunctional secretory organelle

E Crivellato, B Nico, D Ribatti - The Anatomical Record …, 2008 - Wiley Online Library
Chromaffin vesicles (CV) are highly sophisticated secretory organelles synthesized in
adrenal medullary chromaffin cells. They contain a complex mixture of structural proteins …

Cathepsin L colocalizes with chromogranin a in chromaffin vesicles to generate active peptides

N Biswas, JL Rodriguez-Flores, M Courel… - …, 2009 - academic.oup.com
Chromogranin A (CgA), the major soluble protein in chromaffin granules, is proteolytically
processed to generate biologically active peptides including the catecholamine release …

Secretogranin III directs secretory vesicle biogenesis in mast cells in a manner dependent upon interaction with chromogranin A

P Prasad, AA Yanagihara… - The Journal of …, 2008 - journals.aai.org
Mast cells are granular immunocytes that reside in the body's barrier tissues. These cells
orchestrate inflammatory responses. Proinflammatory mediators are stored in granular …

Chromogranin A promotes peptide hormone sorting to mobile granules in constitutively and regulated secreting cells: role of conserved N-and C-terminal peptides

M Montero-Hadjadje, S Elias, L Chevalier… - Journal of Biological …, 2009 - ASBMB
Chromogranin A (CgA) has been proposed to play a major role in the formation of dense-
core secretory granules (DCGs) in neuroendocrine cells. Here, we took advantage of unique …