The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

The tumor microenvironment is proposed to contribute substantially to the progression of
cancers, including breast cancer. Cancer‐associated fibroblasts (CAFs) are the most …

Background METTL3 is known to be involved in all stages in the life cycle of RNA. It affects
the tumor formation by the regulation the m6A modification in the mRNAs of critical …

The tumor microenvironment is a heterogeneous population of cells consisting of the tumor
bulk plus supporting cells. It is becoming increasingly evident that these supporting cells are …

Purpose The present review aimed to assess the role of exosomal miRNAs in cancer-
associated fibroblasts (CAFs), normal fibroblasts (NFs), and cancer cells. The roles of …

Improved treatment of breast cancer, the world's second most common cancer, requires
identification of new sensitive prognostic and diagnostic biomarkers. Exosomes are lipid …

Exosomes are nano-sized membrane vesicles released by a variety of cell types, and are
thought to play important roles in intercellular communications. In breast cancer, through …

The tumor stroma is no longer seen solely as physical support for mutated epithelial cells but
as an important modulator and even a driver of tumorigenicity. Within the tumor stromal …

Cancer-associated fibroblasts (CAFs) are important cells of the tumor microenvironment that
can communicate with tumor cells through various mechanisms. Recently, increasing …

Recent studies indicate that cancer-associated fibroblasts (CAFs) are involved in tumor
growth, invasion and metastasis, however, the underling mechanisms remain unclear. In the …