Hyponatremia is a common water balance disorder that often poses a diagnostic or
therapeutic challenge. Therefore, guidelines were developed by professional organizations …

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Maximizing the potential of human kidney organoids for drug testing and regenerative
medicine and to model development and disease requires addressing cell immaturity, the …

The discovery of aquaporin-1 (AQP1) answered the long-standing biophysical question of
how water specifically crosses biological membranes. In the kidney, at least seven …

▪ Abstract The high water permeability characteristic of mammalian red cell membranes is
now known to be caused by the protein AQP1. This channel freely permits movement of …

Background. Although hyponatraemia [plasma sodium (PNa)< 136 mmol/l] frequently
develops in hospital, risk factors for hospital-acquired hyponatraemia remain unclear …

Disorders of serum sodium are both the most common and probably most the poorly
understood electrolyte disorders in clinical medicine. In the past few years increased …

Although the collecting duct is regarded as the primary site at which mineralocorticoids
regulate renal sodium transport in the kidney, recent evidence points to the distal convoluted …

The discovery of aquaporin membrane water channels by Agre and coworkers answered a
long-standing biophysical question of how water specifically crosses biologic membranes …

This article discusses the pathophysiology of sodium and water retention in edematous
disorders with a particular focus on cardiac failure, cirrhosis, and pregnancy. The body fluid …