Microbial biofilm: a review on formation, infection, antibiotic resistance, control measures, and innovative treatment
S Sharma, J Mohler, SD Mahajan, SA Schwartz… - Microorganisms, 2023 - mdpi.com
Biofilm is complex and consists of bacterial colonies that reside in an exopolysaccharide
matrix that attaches to foreign surfaces in a living organism. Biofilm frequently leads to …
matrix that attaches to foreign surfaces in a living organism. Biofilm frequently leads to …
Antimicrobial stewardship: fighting antimicrobial resistance and protecting global public health
MAA Majumder, S Rahman, D Cohall… - Infection and drug …, 2020 - Taylor & Francis
Antimicrobial resistance (AMR) is a serious threat to global public health. It increases
morbidity and mortality, and is associated with high economic costs due to its health care …
morbidity and mortality, and is associated with high economic costs due to its health care …
CRISPR technologies and the search for the PAM-free nuclease
D Collias, CL Beisel - Nature communications, 2021 - nature.com
The ever-expanding set of CRISPR technologies and their programmable RNA-guided
nucleases exhibit remarkable flexibility in DNA targeting. However, this flexibility comes with …
nucleases exhibit remarkable flexibility in DNA targeting. However, this flexibility comes with …
The pan-immune system of bacteria: antiviral defence as a community resource
A Bernheim, R Sorek - Nature reviews microbiology, 2020 - nature.com
Viruses and their hosts are engaged in a constant arms race leading to the evolution of
antiviral defence mechanisms. Recent studies have revealed that the immune arsenal of …
antiviral defence mechanisms. Recent studies have revealed that the immune arsenal of …
The biology of CRISPR-Cas: backward and forward
F Hille, H Richter, SP Wong, M Bratovič, S Ressel… - Cell, 2018 - cell.com
In bacteria and archaea, clustered regularly interspaced short palindromic repeats
(CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system …
(CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system …
Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems
INTRODUCTION To combat invading pathogens, cells develop an adaptive immune
response by changing their own genetic information. In vertebrates, the generation of …
response by changing their own genetic information. In vertebrates, the generation of …
CRISPR-Cas: biology, mechanisms and relevance
F Hille, E Charpentier - … of the royal society B: biological …, 2016 - royalsocietypublishing.org
Prokaryotes have evolved several defence mechanisms to protect themselves from viral
predators. Clustered regularly interspaced short palindromic repeats (CRISPR) and their …
predators. Clustered regularly interspaced short palindromic repeats (CRISPR) and their …
A compact Cascade–Cas3 system for targeted genome engineering
CRISPR–Cas technologies have enabled programmable gene editing in eukaryotes and
prokaryotes. However, the leading Cas9 and Cas12a enzymes are limited in their ability to …
prokaryotes. However, the leading Cas9 and Cas12a enzymes are limited in their ability to …
[HTML][HTML] The CRISPR-Cas immune system: biology, mechanisms and applications
Viruses are a common threat to cellular life, not the least to bacteria and archaea who
constitute the majority of life on Earth. Consequently, a variety of mechanisms to resist virus …
constitute the majority of life on Earth. Consequently, a variety of mechanisms to resist virus …
CRISPR-Cas: adapting to change
BACKGROUND The arms race between prokaryotes and their perpetually evolving
predators has fueled the evolution of a defense arsenal. The so-called CRISPR-Cas …
predators has fueled the evolution of a defense arsenal. The so-called CRISPR-Cas …