Insulin-like growth factors (IGFs) are peptides which exert mitogenic, endocrine and cytokine
activities. Together with their receptors, binding proteins and associated molecules, they …

The HOXA genes, belonging to the HOX family, encompass 11 members (HOXA1-11) and
exert critical functions in early embryonic development, as well as various adult processes …

Colorectal cancer is a highly heterogeneous disease, with well-characterized subtypes
based on genome, DNA methylome, and transcriptome signatures. To chart the epigenetic …

Background Familial adenomatous polyposis (FAP) is an inherited colorectal cancer (CRC)
syndrome resulting from germ line mutations in the adenomatous polyposis coli (APC) gene …

Human cancers are heterogenous by their cell composition and origination site. Cancer
metastasis generates the conundrum of the unknown origin of migrated tumor cells. Tracing …

Abstract Background/Aim: Squamous cell carcinoma is one of the major subtypes of
esophageal carcinoma, and the 5-year overall survival rate of esophageal squamous cell …

Colorectal cancer (CRC) is the third most common and second most lethal type of cancer
worldwide, presenting major health risks as well as economic costs to both people and …

Obesity with adiposity is a common disorder in modern days, influenced by environmental
factors such as eating and lifestyle habits and affecting the epigenetics of adipose-based …

Publicly available repositories such as Genomic Data Commons or Gene Expression
Omnibus are a valuable research resource useful for hypothesis driven research as well as …

Background and aims An increasing body of observational studies has linked fructose intake
to colorectal cancer (CRC). African Americans (AAs) are significantly more likely than …