The insulin-like growth factor system and colorectal cancer
Insulin-like growth factors (IGFs) are peptides which exert mitogenic, endocrine and cytokine
activities. Together with their receptors, binding proteins and associated molecules, they …
activities. Together with their receptors, binding proteins and associated molecules, they …
Role of HOXA1-4 in the development of genetic and malignant diseases
L Wang, H Sun, L Cao, J Wang - Biomarker Research, 2024 - Springer
The HOXA genes, belonging to the HOX family, encompass 11 members (HOXA1-11) and
exert critical functions in early embryonic development, as well as various adult processes …
exert critical functions in early embryonic development, as well as various adult processes …
Single-cell chromatin accessibility analysis reveals the epigenetic basis and signature transcription factors for the molecular subtypes of colorectal cancers
Z Liu, Y Hu, H Xie, K Chen, L Wen, W Fu, X Zhou… - Cancer Discovery, 2024 - AACR
Colorectal cancer is a highly heterogeneous disease, with well-characterized subtypes
based on genome, DNA methylome, and transcriptome signatures. To chart the epigenetic …
based on genome, DNA methylome, and transcriptome signatures. To chart the epigenetic …
DNA methylation analysis of normal colon organoids from familial adenomatous polyposis patients reveals novel insight into colon cancer development
Background Familial adenomatous polyposis (FAP) is an inherited colorectal cancer (CRC)
syndrome resulting from germ line mutations in the adenomatous polyposis coli (APC) gene …
syndrome resulting from germ line mutations in the adenomatous polyposis coli (APC) gene …
HiTAIC: hi erarchical tumor artificial intelligence classifier traces tissue of origin and tumor type in primary and metastasized tumors using DNA methylation
Human cancers are heterogenous by their cell composition and origination site. Cancer
metastasis generates the conundrum of the unknown origin of migrated tumor cells. Tracing …
metastasis generates the conundrum of the unknown origin of migrated tumor cells. Tracing …
OPLAH Protein Expression Stratifies the Prognosis of Patients With Squamous Cell Carcinoma of the Esophagus
D Shimizu, M Kanda, T Kishida… - Cancer Genomics & …, 2023 - cgp.iiarjournals.org
Abstract Background/Aim: Squamous cell carcinoma is one of the major subtypes of
esophageal carcinoma, and the 5-year overall survival rate of esophageal squamous cell …
esophageal carcinoma, and the 5-year overall survival rate of esophageal squamous cell …
Novel biomarkers used for early diagnosis and tyrosine kinase inhibitors as targeted therapies in colorectal cancer
H Jiang, S Zhou, G Li - Frontiers in pharmacology, 2023 - frontiersin.org
Colorectal cancer (CRC) is the third most common and second most lethal type of cancer
worldwide, presenting major health risks as well as economic costs to both people and …
worldwide, presenting major health risks as well as economic costs to both people and …
Obesity-associated differentially methylated regions in colon cancer
JJ Milner, ZF Chen, J Grayson, SYPK Shiao - Journal of Personalized …, 2022 - mdpi.com
Obesity with adiposity is a common disorder in modern days, influenced by environmental
factors such as eating and lifestyle habits and affecting the epigenetics of adipose-based …
factors such as eating and lifestyle habits and affecting the epigenetics of adipose-based …
[HTML][HTML] eDAVE–Extension of GDC data analysis, visualization, and exploration tools
J Bińkowski, O Taryma-Leśniak, KE Sokolowska… - Computational and …, 2023 - Elsevier
Publicly available repositories such as Genomic Data Commons or Gene Expression
Omnibus are a valuable research resource useful for hypothesis driven research as well as …
Omnibus are a valuable research resource useful for hypothesis driven research as well as …
Potential role of fructose on human colon DNA methylation in racial disparities observed for colorectal cancer risk
MA Devall, S Eaton, G Hu, X Sun, E Jakum… - medRxiv, 2023 - medrxiv.org
Background and aims An increasing body of observational studies has linked fructose intake
to colorectal cancer (CRC). African Americans (AAs) are significantly more likely than …
to colorectal cancer (CRC). African Americans (AAs) are significantly more likely than …