Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

The mammalian NHE (Na+/H+ exchanger) is a ubiquitously expressed integral membrane
protein that regulates intracellular pH by removing a proton in exchange for an extracellular …

Abstract Sodium/proton exchanger 1 (NHE1) is an electroneutral secondary active
transporter present on the plasma membrane of most mammalian cells and plays critical …

Abstract The Na+/H+-exchanger NHE1 and the monocarboxylate transporters MCT1 and
MCT4 are crucial for intracellular pH regulation, particularly under active metabolism. NHE1 …

Tightly coupled exchange of Na+ for H+ occurs across the surface membrane of virtually all
living cells. For years, the underlying molecular entity was unknown and the full …

Eukaryotic Na+/H+ exchangers are transmembrane proteins that are vital for cellular
homeostasis and play key roles in pathological conditions such as cancer and heart …

Na+–H+ antiporters are integral membrane proteins that exchange Na+ for H+ across the
cytoplasmic membrane and many intracellular membranes. They are essential for Na+, pH …

α-Helical membrane proteins fulfill many vital roles in all living cells and constitute the
majority of drug targets. However, their relevance is in no way paralleled by our current …

Apelin peptides are the cognate ligands for the G-protein coupled receptor APJ, with
functions in the cardiovascular and central nervous systems, in glucose metabolism and as …

Mammalian Na+/H+ exchangers of the SLC9A family are widely expressed and involved in
numerous essential physiological processes. Their primary function is to mediate the 1: 1 …