[HTML][HTML] The SLC9A-C mammalian Na+/H+ exchanger family: molecules, mechanisms, and physiology
SF Pedersen, L Counillon - Physiological reviews, 2019 - journals.physiology.org
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …
Structural and functional analysis of the Na+/H+ exchanger
The mammalian NHE (Na+/H+ exchanger) is a ubiquitously expressed integral membrane
protein that regulates intracellular pH by removing a proton in exchange for an extracellular …
protein that regulates intracellular pH by removing a proton in exchange for an extracellular …
Structure and mechanism of the human NHE1-CHP1 complex
Y Dong, Y Gao, A Ilie, DS Kim, A Boucher, B Li… - Nature …, 2021 - nature.com
Abstract Sodium/proton exchanger 1 (NHE1) is an electroneutral secondary active
transporter present on the plasma membrane of most mammalian cells and plays critical …
transporter present on the plasma membrane of most mammalian cells and plays critical …
[HTML][HTML] Na+/H+ antiporter (NHE1) and lactate/H+ symporters (MCTs) in pH homeostasis and cancer metabolism
L Counillon, Y Bouret, I Marchiq… - Biochimica et Biophysica …, 2016 - Elsevier
Abstract The Na+/H+-exchanger NHE1 and the monocarboxylate transporters MCT1 and
MCT4 are crucial for intracellular pH regulation, particularly under active metabolism. NHE1 …
MCT4 are crucial for intracellular pH regulation, particularly under active metabolism. NHE1 …
Na+/H+ Exchangers
J Orlowski, S Grinstein - Comprehensive Physiology, 2011 - Wiley Online Library
Tightly coupled exchange of Na+ for H+ occurs across the surface membrane of virtually all
living cells. For years, the underlying molecular entity was unknown and the full …
living cells. For years, the underlying molecular entity was unknown and the full …
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications
Eukaryotic Na+/H+ exchangers are transmembrane proteins that are vital for cellular
homeostasis and play key roles in pathological conditions such as cancer and heart …
homeostasis and play key roles in pathological conditions such as cancer and heart …
The enlightening encounter between structure and function in the NhaA Na+–H+ antiporter
E Padan - Trends in biochemical sciences, 2008 - cell.com
Na+–H+ antiporters are integral membrane proteins that exchange Na+ for H+ across the
cytoplasmic membrane and many intracellular membranes. They are essential for Na+, pH …
cytoplasmic membrane and many intracellular membranes. They are essential for Na+, pH …
α-Helical transmembrane peptides: a “divide and conquer” approach to membrane proteins
N Bordag, S Keller - Chemistry and physics of lipids, 2010 - Elsevier
α-Helical membrane proteins fulfill many vital roles in all living cells and constitute the
majority of drug targets. However, their relevance is in no way paralleled by our current …
majority of drug targets. However, their relevance is in no way paralleled by our current …
Structural insight into G-protein coupled receptor binding by apelin
DN Langelaan, EM Bebbington, T Reddy… - Biochemistry, 2009 - ACS Publications
Apelin peptides are the cognate ligands for the G-protein coupled receptor APJ, with
functions in the cardiovascular and central nervous systems, in glucose metabolism and as …
functions in the cardiovascular and central nervous systems, in glucose metabolism and as …
Structural dynamics and regulation of the mammalian SLC9A family of Na+/H+ exchangers
R Hendus-Altenburger, BB Kragelund… - Current topics in …, 2014 - Elsevier
Mammalian Na+/H+ exchangers of the SLC9A family are widely expressed and involved in
numerous essential physiological processes. Their primary function is to mediate the 1: 1 …
numerous essential physiological processes. Their primary function is to mediate the 1: 1 …