The search for novel anticancer agents with more selectivity and lower toxicity continues to
be an area of intensive investigation. The unique structural features of spirooxindoles …

Design of small-molecule inhibitors (MDM2 inhibitors) to block the MDM2–p53 protein–
protein interaction has been pursued as a new cancer therapeutic strategy. In recent years …

Spirooxindoles are important synthetic targets possessing extended biological activity and
drug discovery applications. This review focuses on the various strategies for the …

The spirooxindole system is the core structure of a variety of medicinal agents and natural
products. 1, 2 In fact, spirooxindole derivatives have been described with different biological …

Contemporary medicinal chemistry faces diverse challenges from several directions,
including the need for both potency and specificity of any therapeutic agent; the increasingly …

We previously reported the discovery of a class of spirooxindoles as potent and selective
small-molecule inhibitors of the MDM2–p53 interaction (MDM2 inhibitors). We report herein …

Novel dispirooxindole-pyrrolidine derivatives have been synthesized through 1, 3-dipolar
cycloaddition of an azomethine ylide generated from isatin and sarcosine with the …

The catalytic nucleophilic substitution of tertiary alcohols using carbon or heteroatom based
nucleophiles is a versatile methodology for the efficient, diverse and atom economical …

Scaffold modification based on Wang's pioneering MDM2–p53 inhibitors led to novel,
chemically stable spiro-oxindole compounds bearing a spiro [3 H-indole-3, 2′-pyrrolidin]-2 …

The p53–MDM2 interaction has been proved to be a valuable target to develop effective
antitumor agents. Novel p53–MDM2 inhibitors bearing pyrrolidone scaffolds were …