Gene regulation through DNA methylation is a well described phenomenon that has a
prominent role in physiological and pathological cell-states. This epigenetic modification is …

Simple Summary Many molecular biology techniques have been widely used to study the
pathogenesis of different diseases, particularly haematologic malignancies which are …

Dear Editor, Myeloproliferative neoplasms (MPNs) are caused by somatic driver mutations,
such as JAK2V617F, which might also affect cellular aging and senescence. Here, we …

Structural equation models involving latent variables are useful tools for formulating
hypothesized models defined by theoretical variables and causal links between these …

In this study we interrogated the DNA methylome of myelofibrosis patients using high-
density DNA methylation arrays. We detected 35,215 differentially methylated CpG …

Epigenetic machinery is a cornerstone in normal cell development, orchestrating tissue-
specific gene expression in mammalian cells. Aberrations in this intricate landscape drive …

The additional sex combs-like (ASXL) family, a mammalian homolog of the additional sex
combs (Asx) of Drosophila, has been implicated in transcriptional regulation via chromatin …

Simple Summary Myeloproliferative neoplasms (MPN) are clonal hematologic malignancies
with dysregulated myeloid blood cell production driven by JAK2, calreticulin, and MPL gene …

Simple Summary Myelofibrosis refers to fibrosis in the bone marrow associated with certain
bone marrow cancers. It is a characteristic of primary myelofibrosis and may develop later in …

Background Alu repeats, belonging to the Short Interspersed Repetitive Elements (SINEs)
class, contain about 25% of CpG sites in the human genome. Alu sequences lie in gene-rich …