DNA methylation of enhancer elements in myeloid neoplasms: think outside the promoters?
Gene regulation through DNA methylation is a well described phenomenon that has a
prominent role in physiological and pathological cell-states. This epigenetic modification is …
prominent role in physiological and pathological cell-states. This epigenetic modification is …
The Prevalence of TET2 Gene Mutations in Patients with BCR-ABL-Negative Myeloproliferative Neoplasms (MPN): A Systematic Review and Meta-Analysis
Simple Summary Many molecular biology techniques have been widely used to study the
pathogenesis of different diseases, particularly haematologic malignancies which are …
pathogenesis of different diseases, particularly haematologic malignancies which are …
Cellular aging is accelerated in the malignant clone of myeloproliferative neoplasms
M Vieri, V Tharmapalan, M Kalmer, J Baumeister… - Blood Cancer …, 2023 - nature.com
Dear Editor, Myeloproliferative neoplasms (MPNs) are caused by somatic driver mutations,
such as JAK2V617F, which might also affect cellular aging and senescence. Here, we …
such as JAK2V617F, which might also affect cellular aging and senescence. Here, we …
Structural equation modeling and whole-genome scans uncover chromosome regions and enriched pathways for carcass and meat quality in beef
JD Leal-Gutiérrez, FM Rezende, MA Elzo… - Frontiers in …, 2018 - frontiersin.org
Structural equation models involving latent variables are useful tools for formulating
hypothesized models defined by theoretical variables and causal links between these …
hypothesized models defined by theoretical variables and causal links between these …
[HTML][HTML] Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor …
N Martínez-Calle, M Pascual, R Ordoñez… - …, 2019 - ncbi.nlm.nih.gov
In this study we interrogated the DNA methylome of myelofibrosis patients using high-
density DNA methylation arrays. We detected 35,215 differentially methylated CpG …
density DNA methylation arrays. We detected 35,215 differentially methylated CpG …
Deciphering the Epigenetic Symphony of Cancer: Insights and Epigenetic Therapies Implications
F Akram, R Tanveer, S Andleeb… - … in Cancer Research …, 2024 - journals.sagepub.com
Epigenetic machinery is a cornerstone in normal cell development, orchestrating tissue-
specific gene expression in mammalian cells. Aberrations in this intricate landscape drive …
specific gene expression in mammalian cells. Aberrations in this intricate landscape drive …
Additional Sex Combs-like Family Associated with Epigenetic Regulation
N Kim, S Byun, SJ Um - International Journal of Molecular Sciences, 2024 - mdpi.com
The additional sex combs-like (ASXL) family, a mammalian homolog of the additional sex
combs (Asx) of Drosophila, has been implicated in transcriptional regulation via chromatin …
combs (Asx) of Drosophila, has been implicated in transcriptional regulation via chromatin …
Recent advances in molecular diagnostics and targeted therapy of myeloproliferative neoplasms
S Stivala, SC Meyer - Cancers, 2021 - mdpi.com
Simple Summary Myeloproliferative neoplasms (MPN) are clonal hematologic malignancies
with dysregulated myeloid blood cell production driven by JAK2, calreticulin, and MPL gene …
with dysregulated myeloid blood cell production driven by JAK2, calreticulin, and MPL gene …
Molecular Genetic Profile of Myelofibrosis: Implications in the Diagnosis, Prognosis, and Treatment Advancements
T Verma, N Papadantonakis, D Peker Barclift, L Zhang - Cancers, 2024 - mdpi.com
Simple Summary Myelofibrosis refers to fibrosis in the bone marrow associated with certain
bone marrow cancers. It is a characteristic of primary myelofibrosis and may develop later in …
bone marrow cancers. It is a characteristic of primary myelofibrosis and may develop later in …
Droplet digital PCR for the quantification of Alu methylation status in hematological malignancies
P Orsini, L Impera, E Parciante, C Cumbo… - Diagnostic …, 2018 - Springer
Background Alu repeats, belonging to the Short Interspersed Repetitive Elements (SINEs)
class, contain about 25% of CpG sites in the human genome. Alu sequences lie in gene-rich …
class, contain about 25% of CpG sites in the human genome. Alu sequences lie in gene-rich …