Pathogenesis of human immunodeficiency virus infection
JA Levy - Microbiological reviews, 1993 - Am Soc Microbiol
The lentivirus human immunodeficiency virus (HIV) causes AIDS by interacting with a large
number of different cells in the body and escaping the host immune response against it. HIV …
number of different cells in the body and escaping the host immune response against it. HIV …
The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection
S Bour, R Geleziunas, MA Wainberg - Microbiological reviews, 1995 - Am Soc Microbiol
Interactions between the viral envelope glycoprotein gp120 and the cell surface receptor
CD4 are responsible for the entry of human immunodeficiency virus type 1 (HIV-1) into host …
CD4 are responsible for the entry of human immunodeficiency virus type 1 (HIV-1) into host …
Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef-and Vpu-inhibitable manner
Abstract Background: Human immunodeficiency virus-1 (HIV-1) infection decreases the cell-
surface expression of its cellular receptor, CD4, through the combined actions of Nef, Env …
surface expression of its cellular receptor, CD4, through the combined actions of Nef, Env …
Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps
A key function of the Vpu protein of HIV-1 is the targeting of newly-synthesized CD4 for
proteasomal degradation. This function has been proposed to occur by a mechanism that is …
proteasomal degradation. This function has been proposed to occur by a mechanism that is …
The cytopathic effect of HIV is associated with apoptosis
AG Laurent-Crawford, B Krust, S Muller, Y Rivière… - Virology, 1991 - Elsevier
Large amounts of histones, H1, H2A, H2B, H3, and H4, were observed in total extracts of T4
lymphocytes and derived cell lines infected with the human immunodeficiency virus (HIV) …
lymphocytes and derived cell lines infected with the human immunodeficiency virus (HIV) …
Retroviral superinfection resistance
M Nethe, B Berkhout, AC Van der Kuyl - Retrovirology, 2005 - Springer
The retroviral phenomenon of superinfection resistance (SIR) defines an interference
mechanism that is established after primary infection, preventing the infected cell from being …
mechanism that is established after primary infection, preventing the infected cell from being …
Oscillation of the human immunodeficiency virus surface receptor is regulated by the state of viral activation in a CD4+ cell model of chronic infection
ST Butera, VL Perez, BY Wu, GJ Nabel… - Journal of virology, 1991 - Am Soc Microbiol
We have developed a unique physiologic model of chronic human immunodeficiency virus
type 1 (HIV-1) infection, OM-10.1, clonally derived from infected HL-60 promyelocytes and …
type 1 (HIV-1) infection, OM-10.1, clonally derived from infected HL-60 promyelocytes and …
Membrane expression of HIV envelope glycoproteins triggers apoptosis in CD4 cells
AG LAURENT-CRAWFORD, B KRUST… - AIDS research and …, 1993 - liebertpub.com
The cytopathic effect of HIV-1 and HIV-2 in CD4+ lymphocytes has been shown to be
associated with apoptosis or programmed cell death. Using different experimental …
associated with apoptosis or programmed cell death. Using different experimental …
The physiological relevance of CD4 receptor down-modulation during HIV infection
J Lama - Current HIV research, 2003 - ingentaconnect.com
Upon binding to the CD4 receptor the HIV envelope protein undergoes conformational
changes that culminate in the fusion of the viral and cellular membranes. A few hours later, a …
changes that culminate in the fusion of the viral and cellular membranes. A few hours later, a …
Productive human immunodeficiency virus type 1 infection in peripheral blood predominantly takes place in CD4/CD8 double-negative T lymphocytes
P Kaiser, B Joos, B Niederöst, R Weber… - Journal of …, 2007 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) transcription is subject to substantial
fluctuation during the viral life cycle. Due to the low frequencies of HIV-1-infected cells, and …
fluctuation during the viral life cycle. Due to the low frequencies of HIV-1-infected cells, and …