The lentivirus human immunodeficiency virus (HIV) causes AIDS by interacting with a large
number of different cells in the body and escaping the host immune response against it. HIV …

Interactions between the viral envelope glycoprotein gp120 and the cell surface receptor
CD4 are responsible for the entry of human immunodeficiency virus type 1 (HIV-1) into host …

Abstract Background: Human immunodeficiency virus-1 (HIV-1) infection decreases the cell-
surface expression of its cellular receptor, CD4, through the combined actions of Nef, Env …

A key function of the Vpu protein of HIV-1 is the targeting of newly-synthesized CD4 for
proteasomal degradation. This function has been proposed to occur by a mechanism that is …

Large amounts of histones, H1, H2A, H2B, H3, and H4, were observed in total extracts of T4
lymphocytes and derived cell lines infected with the human immunodeficiency virus (HIV) …

The retroviral phenomenon of superinfection resistance (SIR) defines an interference
mechanism that is established after primary infection, preventing the infected cell from being …

We have developed a unique physiologic model of chronic human immunodeficiency virus
type 1 (HIV-1) infection, OM-10.1, clonally derived from infected HL-60 promyelocytes and …

The cytopathic effect of HIV-1 and HIV-2 in CD4+ lymphocytes has been shown to be
associated with apoptosis or programmed cell death. Using different experimental …

Upon binding to the CD4 receptor the HIV envelope protein undergoes conformational
changes that culminate in the fusion of the viral and cellular membranes. A few hours later, a …

Human immunodeficiency virus type 1 (HIV-1) transcription is subject to substantial
fluctuation during the viral life cycle. Due to the low frequencies of HIV-1-infected cells, and …