Nitric oxide signaling in health and disease
JO Lundberg, E Weitzberg - Cell, 2022 - cell.com
The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …
cells and serves to regulate a multitude of physiological processes has continued to …
Cellular and molecular pathobiology of heart failure with preserved ejection fraction
Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …
GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling
VAN Kraft, CT Bezjian, S Pfeiffer… - ACS central …, 2019 - ACS Publications
Ferroptosis is an iron-dependent form of regulated cell death linking iron, lipid, and
glutathione levels to degenerative processes and tumor suppression. By performing a …
glutathione levels to degenerative processes and tumor suppression. By performing a …
NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets
Y Zhang, P Murugesan, K Huang, H Cai - Nature Reviews Cardiology, 2020 - nature.com
Reactive oxygen species (ROS)-dependent production of ROS underlies sustained
oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases …
oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases …
Treating oxidative stress in heart failure: past, present and future
A van der Pol, WH van Gilst, AA Voors… - European Journal of …, 2019 - Wiley Online Library
Advances in cardiovascular research have identified oxidative stress as an important
pathophysiological pathway in the development and progression of heart failure. Oxidative …
pathophysiological pathway in the development and progression of heart failure. Oxidative …
The role of oxidative stress in cardiac disease: from physiological response to injury factor
R D'Oria, R Schipani, A Leonardini… - Oxidative medicine …, 2020 - Wiley Online Library
Reactive oxygen species (ROS) are highly reactive chemical species containing oxygen,
controlled by both enzymatic and nonenzymatic antioxidant defense systems. In the heart …
controlled by both enzymatic and nonenzymatic antioxidant defense systems. In the heart …
Nitric oxide signalling in cardiovascular health and disease
C Farah, LYM Michel, JL Balligand - Nature Reviews Cardiology, 2018 - nature.com
Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …
Measurement of reactive oxygen species, reactive nitrogen species, and redox-dependent signaling in the cardiovascular system: a scientific statement from the …
Reactive oxygen species and reactive nitrogen species are biological molecules that play
important roles in cardiovascular physiology and contribute to disease initiation …
important roles in cardiovascular physiology and contribute to disease initiation …
Mitochondrial calcium overload is a key determinant in heart failure
G Santulli, W Xie, SR Reiken… - Proceedings of the …, 2015 - National Acad Sciences
Calcium (Ca2+) released from the sarcoplasmic reticulum (SR) is crucial for excitation–
contraction (E–C) coupling. Mitochondria, the major source of energy, in the form of ATP …
contraction (E–C) coupling. Mitochondria, the major source of energy, in the form of ATP …
Role of nitric oxide in the cardiovascular and renal systems
The gasotransmitters are a family of gaseous signaling molecules which are produced
endogenously and act at specific receptors to play imperative roles in physiologic and …
endogenously and act at specific receptors to play imperative roles in physiologic and …