Inflammation and Alzheimer's disease: mechanisms and therapeutic implications by natural products

MA Rather, A Khan, S Alshahrani… - Mediators of …, 2021 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disorder with no clear causative event
making the disease difficult to diagnose and treat. The pathological hallmarks of AD include …

Current advances on the phytochemical composition, pharmacologic effects, toxicology, and product development of Phyllanthi Fructus

X Yan, Q Li, L Jing, S Wu, W Duan, Y Chen… - Frontiers in …, 2022 - frontiersin.org
Phyllanthi Fructus (PF), the edible fruits of Phyllanthus emblica L., serves as an important
resource for some health products, foods and drugs due to its high safety and sufficient …

Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies

AV Skalny, M Aschner, Y Jiang, YG Gluhcheva… - Advances in …, 2021 - Elsevier
Recent studies have demonstrated that brain may be considered as the target for aluminium
(Al) toxicity, resulting in development of neurodegenerative and neurodevelopmental …

[HTML][HTML] Aluminum induces neuroinflammation via P2X7 receptor activating NLRP3 inflammasome pathway

X Zhu, W Hao, Z Liu, Y Song, C Hao, S Wu, X Lu… - Ecotoxicology and …, 2023 - Elsevier
Introduction Aluminum is everywhere in nature and is a recognized neurotoxicant closely
associated with various neurodegenerative diseases. Neuroinflammation occurs in the early …

A review of the epidemiological and laboratory evidence of the role of aluminum exposure in pathogenesis of cardiovascular diseases

AA Tinkov, AV Skalny, JL Domingo… - Environmental …, 2024 - Elsevier
The objective of the present study was to review the epidemiological and laboratory
evidence on the role of aluminum (Al) exposure in the pathogenesis of cardiovascular …

Protective effect of magnetic water against AlCl3-induced hepatotoxicity in rats

SA El-Shazly, A Alhejely, HK Alghibiwi… - Scientific Reports, 2024 - nature.com
This study aimed to examine whether or not aluminum chloride (AlCl3)-induced
hepatotoxicity might be mitigated using magnetic water (MW) in rats. This study involved 28 …

The Rho kinase inhibitor fasudil attenuates Aβ1–42-induced apoptosis via the ASK1/JNK signal pathway in primary cultures of hippocampal neurons

Y Gao, Y Yan, Q Fang, N Zhang, G Kumar… - Metabolic brain …, 2019 - Springer
Abstract Alzheimer's disease (AD), a chronic, progressive, neurodegenerative disorder, is
the most common type of dementia. Beta amyloid (Aβ) peptide aggregation and …

Kai-xin-san improves cognitive impairment via wnt/β-catenin and IRE1/XBP1s signalings in APP/PS1 mice

YM Xu, FM Lu, HC Xu, J Zhang, SY Hei… - Rejuvenation …, 2023 - liebertpub.com
Alzheimer's disease (AD) is the most common type of dementia with an insidious onset and
slow progression. Kai-Xin-San (KXS) has been reported to be effective in improving …

Erigeron breviscapus (Vant.) Hand-Mazz.: A Promising Natural Neuroprotective Agent for Alzheimer's Disease

X Dong, S Qu - Frontiers in Pharmacology, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most common neurodegenerative disease and is
characterized by progressive cognitive dysfunction and memory loss in the elderly, which …

Recent advances in the potential of Phyllanthus emblica L. and its related foods for combating metabolic diseases through methylglyoxal trapping: Phyllanthus …

SY Chen, IC Chiang, YY Chen, YH Hsu… - Food Research …, 2024 - Elsevier
Methylglyoxal (MG) serves as the primary precursor for the nonenzymatic glycation of
proteins and DNA, leading to advanced glycation end products (AGEs). Regular intake of …