Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases

A Roohbakhsh, H Parhiz, F Soltani, R Rezaee… - Life sciences, 2015 - Elsevier
Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species
that have various biological properties, particularly those for the prevention of cancer and …

Hesperidin, a bioflavonoid in cancer therapy: a review for a mechanism of action through the modulation of cell signaling pathways

AH Rahmani, AY Babiker, S Anwar - Molecules, 2023 - mdpi.com
Cancer represents one of the most frequent causes of death in the world. The current
therapeutic options, including radiation therapy and chemotherapy, have various adverse …

Acute and sub-chronic oral toxicity studies of hesperidin isolated from orange peel extract in Sprague Dawley rats

Y Li, AD Kandhare, AA Mukherjee… - Regulatory Toxicology …, 2019 - Elsevier
Citrus sinensis contains glycoside hesperetin-7-rhamnoglucoside (hesperidin) which harbor
an array of therapeutic potentials including antioxidant, anticancer, and anti-inflammatory …

Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions

A Visnagri, AD Kandhare, S Chakravarty… - Pharmaceutical …, 2014 - Taylor & Francis
Aim: Diabetic neuropathy (DN) is one of the most common long-term complications of
diabetes mellitus and clinically can be characterized by an elevated nociceptive response …

Therapeutic potential of hesperidin and its aglycone hesperetin: Cell cycle regulation and apoptosis induction in cancer models

JMPF de Oliveira, C Santos, E Fernandes - Phytomedicine, 2020 - Elsevier
Background The ability of cancer cells to divide without restriction and to escape
programmed cell death is a feature of the proliferative state. Citrus flavanones are flavonoids …

[HTML][HTML] Hesperidin, a plant flavonoid accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats: Role of TGF-ß/Smads and Ang-1/Tie-2 …

W Li, AD Kandhare, AA Mukherjee, SL Bodhankar - EXCLI journal, 2018 - ncbi.nlm.nih.gov
Background: Delayed wound healing is a diverse, multifactorial, complex and inter-related
complication of diabetes resulting in significant clinical morbidity. Hesperidin possesses …

Oxidative stress and cancer; the role of hesperidin, a citrus natural bioflavonoid, as a cancer chemoprotective agent

A Ahmadi, A Shadboorestan - Nutrition and cancer, 2016 - Taylor & Francis
Cancer is the third cause of death worldwide, with complex etiology, and is defined as an
uncontrolled growth of cells. A high proportion of cancer incidence and deaths are due to …

Protective effect of mirtazapine and hesperidin on cyclophosphamide-induced oxidative damage and infertility in rat ovaries

NF Khedr - Experimental biology and medicine, 2015 - journals.sagepub.com
Cyclophosphamide (CP) causes infertility due to ovarian toxicity. The toxicity mechanism
suggests oxidative stress. We assessed whether mirtazapine (MTZ) and hesperidin (HSP) …

Therapeutic efficacy of Nano-formulation of lactoperoxidase and lactoferrin via promoting immunomodulatory and apoptotic effects

EM El-Fakharany, M Ashry, AEH Abd-Elaleem… - International Journal of …, 2022 - Elsevier
This study identifies promising potential of a novel and safer nanocombination of bovine milk
lactoperoxidase (LPO) and lactoferrin (LF) to target breast cancer in vitro and in adult female …

Comparison Among Garlic, Berberine, Resveratrol, Hibiscus sabdariffa, Genus Zizyphus, Hesperidin, Red Beetroot, Catha edulis, Portulaca oleracea, and Mulberry …

AR Amin, RB Kassab… - Natural Product …, 2020 - journals.sagepub.com
Diabetes mellitus (DM) and hypertension are 2 of the most prevalent diseases with poor
impact on health status worldwide. In most cases, they coexist with other metabolic disorders …