Poorly water-soluble drugs continue to be a problematic, yet important class of
pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in …

Oral administration is the most common route of drug delivery. The absorption of a drug from
the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of …

The recent impact of the Biopharmaceutics Classification System (BCS) and the
Biopharmaceutics Drug Disposition Classification System (BDDCS) on relevant scientific …

The availability of in vitro tools that are constructed on the basis of a detailed knowledge of
key aspects of gastrointestinal (GI) physiology and their impact on formulation performance …

Many concepts of oral drug delivery are based on our comprehension of human
gastrointestinal physiology. Unfortunately, we tend to oversimplify the complex interplay …

The intraluminal conditions of the fed stomach are critical for drug release from solid oral
dosage forms and thus, often associated with the occurrence of food effects on oral …

This Article shares the proceedings from the August 29th, 2023 (day 1) workshop
“Physiologically Based Biopharmaceutics Modeling (PBBM) Best Practices for Drug Product …

The rate and extent of drug dissolution in the gastrointestinal (GI) tract are highly dependent
upon drug physicochemical properties and GI fluid properties. Biorelevant dissolution media …

Gene therapy with RNA and pDNA-based drugs is limited by poor enzymatic stability and
poor cellular permeation. The delivery of nucleic acids, in particular by the oral route …

Background Physiologically-based population pharmacokinetic modeling (popPBPK)
coupled with in vitro biopharmaceutics tools such as biorelevant dissolution testing can …