Hypertonic saline has been in clinical use for many decades. Its osmotic and volume‐
expanding properties make it theoretically useful for a number of indications in critical care …

Sepsis results in disruption of the endothelial glycocalyx layer and damage to the
microvasculature, resulting in interstitial accumulation of fluid and subsequently edema …

Context Administration of traditional chloride-liberal intravenous fluids may precipitate acute
kidney injury (AKI). Objective To assess the association of a chloride-restrictive (vs chloride …

Importance Evidence supporting the choice of intravenous colloid vs crystalloid solutions for
management of hypovolemic shock remains unclear. Objective To test whether use of …

Background There is insufficient research into the use of mechanical ventilation with
increased inspiratory oxygen concentration (FiO 2) and fluid resuscitation with hypertonic …

Cell volume regulation is a primitive response to alterations in environmental osmolarity.
The NLRP3 inflammasome is a multiprotein complex that senses pathogen-and danger …

Introduction Hypertonic saline solution (HSS) and a moderate Na restriction plus high
furosemide dose showed beneficial effects in compensated heart failure (HF), in short and …

Abstract The Working Group on Emergency Mass Critical Care was convened by the Center
for Biosecurity of the University of Pittsburgh Medical Center and the Society of Critical Care …

As evidence on fluid resuscitation evolves, a reasonable approach would be to use primarily
balanced crystalloids, consider 2–3 l for initial fluid resuscitation of hypovolemic or …

Background The resuscitation strategy for hemorrhagic shock remains controversial, with the
kidney being especially prone to hypoxia. Methods The authors used a three-phase …