Feature selection techniques have been used as the workhorse in biomarker discovery
applications for a long time. Surprisingly, the stability of feature selection with respect to …

A volcano plot displays unstandardized signal (eg log-fold-change) against noise-
adjusted/standardized signal (eg t-statistic or-log10 (p-value) from the t-test). We review the …

Background Assays of the abundance of immune cell populations in the tumor
microenvironment promise to inform immune oncology research and the choice of …

Abstract RNA-sequencing (RNA-seq) has rapidly become a popular tool to characterize
transcriptomes. A fundamental research problem in many RNA-seq studies is the …

Background: Microarray technologies have identified imbalances in the expression of
specific genes and biological pathways in Alzheimer's disease (AD) brains. However, there …

Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality
worldwide. Defects in trophoblast invasion, differentiation of extravillous trophoblasts and …

More than 8,000 genes are turned on or off as progenitor cells produce the 7 classes of
retinal cell types during development. Thousands of enhancers are also active in the …

Ranked gene lists are highly instable in the sense that similar measures of differential gene
expression may yield very different rankings, and that a small change of the data set usually …

Background Our objective was to develop a consistent molecular definition of psoriasis.
There have been several published microarray studies of psoriasis, and we compared …

Most of current gene expression signatures for cancer prognosis are based on risk scores,
usually calculated as some summaries of expression levels of the signature genes, whose …