Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson
disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis …

Transactive response DNA-binding protein-43 (TDP-43) is an RNA/DNA binding protein that
forms phosphorylated and ubiquitinated aggregates in the cytoplasm of motor neurons in …

Protein aggregation and dysfunction of the ubiquitin-proteasome system are hallmarks of
many neurodegenerative diseases. Here, we address the elusive link between these …

The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …

TDP‐43 is the major component of pathological inclusions in most ALS patients and in up to
50% of patients with frontotemporal dementia (FTD). Heterozygous missense mutations in …

Amyotrophic lateral sclerosis (ALS) is a disease caused by the degeneration of motor
neurons (MNs) leading to progressive muscle weakness and atrophy. Several molecular …

Disrupted nucleocytoplasmic transport (NCT) has been implicated in neurodegenerative
disease pathogenesis; however, the mechanisms by which disrupted NCT causes …

Macroautophagy/autophagy is a major pathway for the clearance of protein aggregates and
damaged organelles, and multiple intracellular organelles participate in the process of …

Mutations in the ER-associated VAPB/ALS8 protein cause amyotrophic lateral sclerosis and
spinal muscular atrophy. Previous studies have argued that ER stress may underlie the …

The best global seller among oncology drugs in 2018 is lenalidomide, an analog of
thalidomide. It took 53 years and a circuitous route from the discovery of thalidomide to …