Citrus flavonoids as promising phytochemicals targeting diabetes and related complications: A systematic review of in vitro and in vivo studies

GR Gandhi, ABS Vasconcelos, DT Wu, HB Li… - Nutrients, 2020 - mdpi.com
The consumption of plant-based food is important for health promotion, especially
concerning the prevention and management of chronic diseases. Flavonoids are the main …

Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview

J Zhao, J Yang, Y Xie - International journal of pharmaceutics, 2019 - Elsevier
Although flavonoid compounds have various pharmacological applications, they generally
exhibit low oral bioavailability due to their poor aqueous solubility. To address this problem …

Therapeutic effects of citrus flavonoids neohesperidin, hesperidin and its aglycone, hesperetin on bone health

AC Ortiz, SOM Fideles, CHB Reis, MZ Bellini… - Biomolecules, 2022 - mdpi.com
Flavonoids are natural phytochemicals that have therapeutic effects and act in the
prevention of several pathologies. These phytochemicals can be found in seeds, grains, tea …

Orcinol glucoside improves senile osteoporosis through attenuating oxidative stress and autophagy of osteoclast via activating Nrf2/Keap1 and mTOR signaling …

W Gong, M Liu, Q Zhang, Q Zhang… - Oxidative Medicine …, 2022 - Wiley Online Library
Oxidative stress and autophagy play essential roles in the development of senile
osteoporosis which is characterized by disrupted osteoclastic bone resorption and …

Neohesperidin attenuates obesity by altering the composition of the gut microbiota in high‐fat diet‐fed mice

JF Lu, MQ Zhu, H Zhang, H Liu, B Xia… - The FASEB …, 2020 - Wiley Online Library
Obesity and related metabolic disorders are associated with intestinal microbiota dysbiosis,
disrupted intestinal barrier, and chronic inflammation. Neohesperidin (Neo), a natural …

Recent advances in the biosynthesis, bioavailability, toxicology, pharmacology, and controlled release of citrus neohesperidin

S Akhter, MSI Arman, MA Tayab… - Critical Reviews in …, 2024 - Taylor & Francis
Abstract Neohesperidin (hesperetin 7-O-neohesperidoside), a well-known flavanone
glycoside widely found in citrus fruits, exhibits a variety of biological activities, with potential …

How zoledronic acid improves osteoporosis by acting on osteoclasts

B Wang, Y Zhan, L Yan, D Hao - Frontiers in Pharmacology, 2022 - frontiersin.org
Osteoporosis is called a silent disease, because it is difficult to detect until comprehensive
examinations for osteoporosis are performed or osteoporotic fractures occur. Zoledronic acid …

Recovery of bioactive compounds from Calabrian bergamot citrus waste: Selection of best green extraction

A Gattuso, A Piscopo, R Romeo, A De Bruno, M Poiana - Agriculture, 2023 - mdpi.com
The purpose of this study was to select the best green extraction technique to recover the
bioactive compounds in Calabrian Bergamot waste (Pomace). Different experimental …

Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes

W Xiao-He, DAI Ce, W Jun, LIU Rui, LI Lei… - Chinese journal of …, 2021 - Elsevier
During the pathogensis of rheumatoid arthritis (RA), activated RA fibroblast-like synoviocytes
(RA-FLSs) combines similar proliferative features as tumor and inflammatory features as …

Marantodes pumilum Var Alata (Kacip Fatimah) ameliorates derangement in RANK/RANKL/OPG pathway and reduces inflammation and oxidative stress in the bone …

K Karim, N Giribabu, N Salleh - Phytomedicine, 2021 - Elsevier
Background M. pumilum has been claimed to protect the bone against the adverse effect of
estrogen deficiency. Additionally, it also exhibits anti-diabetic activity. In view of these, this …