Curcumin-Incorporated Biomaterials: In silico and in vitro evaluation of biological potentials
Curcumin (diferuloylmethane) is the main constituent extracted from turmeric. This
polyphenol is a non-toxic, potent compound with anticancer, anti-inflammatory, antibacterial …
polyphenol is a non-toxic, potent compound with anticancer, anti-inflammatory, antibacterial …
Integrating molecular docking and molecular dynamics simulations
Computational methods, applied at the early stages of the drug design process, use current
technology to provide valuable insights into the understanding of chemical systems in a …
technology to provide valuable insights into the understanding of chemical systems in a …
Acetogenins as potential anticancer agents
M Mangal, M Imran Khan… - Anti-Cancer Agents in …, 2016 - ingentaconnect.com
Acetogenins (ACG) are naturally occurring compounds that are chemically one of the least
investigated families. In the review, we have provided a comprehensive listing of 133 of …
investigated families. In the review, we have provided a comprehensive listing of 133 of …
Novel scaffold hopping of potent benzothiazole and isatin analogues linked to 1, 2, 3-triazole fragment that mimic quinazoline epidermal growth factor receptor …
N Rezki, MA Almehmadi, S Ihmaid, AM Shehata… - Bioorganic …, 2020 - Elsevier
A series of benzothiazole/isatin linked to 1, 2, 3-triazole moiety and terminal sulpha drugs 5a-
e and 6a-e were synthesized and evaluated for cytotoxic activity against a panel of cancer …
e and 6a-e were synthesized and evaluated for cytotoxic activity against a panel of cancer …
Cytotoxicity of the indole alkaloid reserpine from Rauwolfia serpentina against drug-resistant tumor cells
SAA Abdelfatah, T Efferth - Phytomedicine, 2015 - Elsevier
Background: The antihypertensive reserpine is an indole alkaloid from Rauwolfia serpentina
and exerts also profound activity against cancer cells in vitro and in vivo. The present …
and exerts also profound activity against cancer cells in vitro and in vivo. The present …
In-Silico molecular screening of natural compounds as a potential therapeutic inhibitor for Methicillin-resistant Staphylococcus aureus inhibition
Methicillin-resistant Staphylococcus aureus (MRSA) is a life-threatening superbug causing
infectious diseases such as pneumonia, endocarditis, osteomyelitis, etc. Conventional …
infectious diseases such as pneumonia, endocarditis, osteomyelitis, etc. Conventional …
Analysis of SYK gene as a prognostic biomarker and suggested potential bioactive phytochemicals as an alternative therapeutic option for colorectal cancer: an in …
Background: SYK gene regulates the expression of SYK kinase (Spleen tyrosine kinase), an
important non-receptor protein-tyrosine kinase for immunological receptor-mediated …
important non-receptor protein-tyrosine kinase for immunological receptor-mediated …
QSAR based model for discriminating EGFR inhibitors and non-inhibitors using Random forest
Abstract Background Epidermal Growth Factor Receptor (EGFR) is a well-characterized
cancer drug target. In the past, several QSAR models have been developed for predicting …
cancer drug target. In the past, several QSAR models have been developed for predicting …
[HTML][HTML] Effect of curcumin on attenuation of liver cirrhosis via genes/proteins and pathways: A system pharmacology study
Background: Liver cirrhosis is a life-threatening seqsuel of many chronic liver disorders of
varying etiologies. In this study, we investigated protein targets of curcumin in liver cirrhosis …
varying etiologies. In this study, we investigated protein targets of curcumin in liver cirrhosis …
Cucurbitacin IIb induces apoptosis and cell cycle arrest through regulating EGFR/MAPK pathway
Y Liang, T Zhang, L Ren, S Jing, Z Li, P Zuo, T Li… - Environmental …, 2021 - Elsevier
Highlights•Cucurbitacin IIb (CuIIb) exhibited the proliferation inhibitory activity in A549
cells.•CuIIb induced apoptosis via STAT3 pathway.•CuIIb suppressed the cell cycle and …
cells.•CuIIb induced apoptosis via STAT3 pathway.•CuIIb suppressed the cell cycle and …