Virulence Regulation and Innate Host Response in the Pathogenicity of Vibrio cholerae
T Ramamurthy, RK Nandy… - Frontiers in Cellular …, 2020 - frontiersin.org
The human pathogen Vibrio cholerae is the causative agent of severe diarrheal disease
known as cholera. Of the more than 200 “O” serogroups of this pathogen, O1 and O139 …
known as cholera. Of the more than 200 “O” serogroups of this pathogen, O1 and O139 …
Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase
The dual functions of TMEM16F as Ca2+-activated ion channel and lipid scramblase raise
intriguing questions regarding their molecular basis. Intrigued by the ability of the FDA …
intriguing questions regarding their molecular basis. Intrigued by the ability of the FDA …
Polymodal control of TMEM16x channels and scramblases
E Agostinelli, P Tammaro - International Journal of Molecular Sciences, 2022 - mdpi.com
The TMEM16A/anoctamin-1 calcium-activated chloride channel (CaCC) contributes to a
range of vital functions, such as the control of vascular tone and epithelial ion transport. The …
range of vital functions, such as the control of vascular tone and epithelial ion transport. The …
Anoctamin 8 tethers endoplasmic reticulum and plasma membrane for assembly of Ca2+ signaling complexes at the ER/PM compartment
Communication and material transfer between membranes and organelles take place at
membrane contact sites (MCSs). MCSs between the ER and PM, the ER/PM junctions, are …
membrane contact sites (MCSs). MCSs between the ER and PM, the ER/PM junctions, are …
Regulation of TMEM16A/ANO1 and TMEM16F/ANO6 ion currents and phospholipid scrambling by Ca2+ and plasma membrane lipid
R Schreiber, J Ousingsawat… - The Journal of …, 2018 - Wiley Online Library
Key points TMEM16 proteins can operate as Ca2+‐activated Cl− channels or scramble
membrane phospholipids, which are both highly relevant mechanisms during disease …
membrane phospholipids, which are both highly relevant mechanisms during disease …
A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca2+-activated Cl− channel ANO1 (TMEM16A)
ANO1 (TMEM16A) is a Ca2+-activated Cl− channel that regulates diverse cellular functions
including fluid secretion, neuronal excitability, and smooth muscle contraction. ANO1 is …
including fluid secretion, neuronal excitability, and smooth muscle contraction. ANO1 is …
Phosphatidylinositol 4, 5-bisphosphate, cholesterol, and fatty acids modulate the calcium-activated chloride channel TMEM16A (ANO1)
JJ De Jesús-Pérez, S Cruz-Rangel… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Abstract The TMEM16A-mediated Ca 2+-activated Cl− current drives several important
physiological functions. Membrane lipids regulate ion channels and transporters but their …
physiological functions. Membrane lipids regulate ion channels and transporters but their …
Gating and regulatory mechanisms of TMEM16 ion channels and scramblases
The transmembrane protein 16 (TMEM16) family consists of Ca2+-activated ion channels
and Ca2+-activated phospholipid scramblases (CaPLSases) that passively flip-flop …
and Ca2+-activated phospholipid scramblases (CaPLSases) that passively flip-flop …
Anion and cation permeability of the mouse TMEM16F calcium-activated channel
S Stabilini, A Menini, S Pifferi - International Journal of Molecular …, 2021 - mdpi.com
TMEM16F is involved in several physiological processes, such as blood coagulation, bone
development and virus infections. This protein acts both as a Ca2+-dependent phospholipid …
development and virus infections. This protein acts both as a Ca2+-dependent phospholipid …
Zinc ameliorates intestinal barrier dysfunctions in shigellosis by reinstating claudin-2 and-4 on the membranes
Whether zinc (Zn2+) regulates barrier functions by modulating tight-junction (TJ) proteins
when pathogens such as Shigella alter epithelial permeability is still unresolved. We …
when pathogens such as Shigella alter epithelial permeability is still unresolved. We …