Biological determinants impact the neurovascular toxicity of nicotine and tobacco smoke: A pharmacokinetic and pharmacodynamics perspective

SR Archie, S Sharma, E Burks, T Abbruscato - Neurotoxicology, 2022 - Elsevier
Accumulating evidence suggests that the detrimental effect of nicotine and tobacco smoke
on the central nervous system (CNS) is caused by the neurotoxic role of nicotine on blood …

Alcohol consumption effect on antiretroviral therapy and HIV-1 pathogenesis: role of cytochrome P450 isozymes

S Kumar, M Jin, A Ande, N Sinha… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Alcohol consumption, which is highly prevalent in HIV-infected individuals,
poses serious concerns in terms of rate of acquisition of HIV-1 infection, HIV-1 replication …

Electronic cigarette aerosol induces significantly less cytotoxicity than tobacco smoke

D Azzopardi, K Patel, T Jaunky… - Toxicology …, 2016 - Taylor & Francis
Electronic cigarettes (E-cigarettes) are a potential means of addressing the harm to public
health caused by tobacco smoking by offering smokers a less harmful means of receiving …

Effect of benzo (a) pyrene on oxidative stress and inflammatory mediators in astrocytes and HIV-infected macrophages

A Kumar, N Sinha, S Kodidela, L Zhou, UP Singh… - PLoS …, 2022 - journals.plos.org
Background Benzo (a) pyrene (BaP), an important polycyclic aromatic hydrocarbons (PAH)
component of cigarette/tobacco smoking, is known to cause adverse health effects and is …

Nicotine Impairs Macrophage Control of Mycobacterium tuberculosis

X Bai, JA Stitzel, A Bai, CA Zambrano… - American journal of …, 2017 - atsjournals.org
Pure nicotine impairs macrophage killing of Mycobacterium tuberculosis (MTB), but it is not
known whether the nicotine component in cigarette smoke (CS) plays a role. Moreover, the …

Cytokine profiling of exosomes derived from the plasma of HIV-infected alcohol drinkers and cigarette smokers

S Kodidela, S Ranjit, N Sinha, C McArthur, A Kumar… - PloS one, 2018 - journals.plos.org
Cytokines and chemokines circulate in plasma and may be transferred to distant sites, via
exosomes. HIV infection is associated with dysregulation of cytokines and chemokines …

Reduced biological effect of e-cigarette aerosol compared to cigarette smoke evaluated in vitro using normalized nicotine dose and RNA-seq-based toxicogenomics

LE Haswell, A Baxter, A Banerjee, I Verrastro… - Scientific Reports, 2017 - nature.com
Electronic cigarettes (e-cigarettes) use has increased globally and could potentially offer a
lower risk alternative to cigarette smoking. Here, we assessed the transcriptional response …

Effects of cigarette smoke condensate on oxidative stress, apoptotic cell death, and HIV replication in human monocytic cells

PSS Rao, A Ande, N Sinha, A Kumar, S Kumar - PloS one, 2016 - journals.plos.org
While cigarette smoking is prevalent amongst HIV-infected patients, the effects of cigarette
smoke constituents in cells of myeloid lineage are poorly known. Recently, we have shown …

Luteolin alleviates oxidative stress in chronic obstructive pulmonary disease induced by cigarette smoke via modulation of the TRPV1 and CYP2A13/NRF2 signaling …

L Zhou, T Jian, Y Wan, R Huang, H Fang… - International Journal of …, 2023 - mdpi.com
The current study aims to investigate the therapeutic potential of luteolin (Lut), a naturally
occurring flavonoid found in various medicinal plants, for treating chronic obstructive …

[HTML][HTML] Detection of vascular inflammation and oxidative stress by cotinine in smokers: Measured through interleukin-6 and superoxide dismutase

K Kumboyono, IN Chomsy, AK Hakim… - … Journal of General …, 2022 - ncbi.nlm.nih.gov
Purpose Smoking is a significant risk factor in developing cardiovascular disease
pathogenesis through oxidative stress and inflammation mechanisms. This study used …