The MRE11–RAD50–NBS1 complex conducts the orchestration of damage signaling and outcomes to stress in DNA replication and repair
Genomic instability in disease and its fidelity in health depend on the DNA damage
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
Mechanism and regulation of DNA end resection in eukaryotes
LS Symington - Critical reviews in biochemistry and molecular …, 2016 - Taylor & Francis
The repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is
initiated by nucleolytic degradation of the 5′-terminated strands in a process termed end …
initiated by nucleolytic degradation of the 5′-terminated strands in a process termed end …
Coiled‐coils: The long and short of it
L Truebestein, TA Leonard - Bioessays, 2016 - Wiley Online Library
Coiled‐coils are found in proteins throughout all three kingdoms of life. Coiled‐coil domains
of some proteins are almost invariant in sequence and length, betraying a structural and …
of some proteins are almost invariant in sequence and length, betraying a structural and …
Phosphorylated CtIP functions as a co-factor of the MRE11-RAD50-NBS1 endonuclease in DNA end resection
To repair a DNA double-strand break (DSB) by homologous recombination (HR), the 5′-
terminated strand of the DSB must be resected. The human MRE11-RAD50-NBS1 (MRN) …
terminated strand of the DSB must be resected. The human MRE11-RAD50-NBS1 (MRN) …
Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks
To repair double-strand DNA breaks by homologous recombination, the 5′-terminated
DNA strand must first be resected, which generates 3′ single-stranded DNA overhangs …
DNA strand must first be resected, which generates 3′ single-stranded DNA overhangs …
Double-strand break end resection and repair pathway choice
LS Symington, J Gautier - Annual review of genetics, 2011 - annualreviews.org
DNA double-strand breaks (DSBs) are cytotoxic lesions that can result in mutagenic events
or cell death if left unrepaired or repaired inappropriately. Cells use two major pathways for …
or cell death if left unrepaired or repaired inappropriately. Cells use two major pathways for …
[HTML][HTML] Properties and behavior of carbon nanomaterials when interfacing neuronal cells: How far have we come?
In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …
components based on carbon-(nano) materials in the engineering of neural interfaces, to …
[HTML][HTML] Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions
M Rotheneder, K Stakyte, E van de Logt, JD Bartho… - Molecular cell, 2023 - cell.com
The DNA double-strand break repair complex Mre11-Rad50-Nbs1 (MRN) detects and
nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break …
nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break …
Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae
LS Symington, R Rothstein, M Lisby - Genetics, 2014 - academic.oup.com
Homology-dependent exchange of genetic information between DNA molecules has a
profound impact on the maintenance of genome integrity by facilitating error-free DNA …
profound impact on the maintenance of genome integrity by facilitating error-free DNA …
Repair of double-strand breaks by end joining
KK Chiruvella, Z Liang… - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
Nonhomologous end joining (NHEJ) refers to a set of genome maintenance pathways in
which two DNA double-strand break (DSB) ends are (re) joined by apposition, processing …
which two DNA double-strand break (DSB) ends are (re) joined by apposition, processing …