Single-cell profiling of tumour evolution in multiple myeloma—opportunities for precision medicine
Multiple myeloma (MM) is a haematological malignancy of plasma cells characterized by
substantial intraclonal genetic heterogeneity. Although therapeutic advances made in the …
substantial intraclonal genetic heterogeneity. Although therapeutic advances made in the …
Clonal evolution in hematological malignancies and therapeutic implications
The ability of cancer to evolve and adapt is a principal challenge to therapy in general and to
the paradigm of targeted therapy in particular. This ability is fueled by the co-existence of …
the paradigm of targeted therapy in particular. This ability is fueled by the co-existence of …
Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms
The mechanisms involved in the progression from monoclonal gammopathy of
undetermined significance (MGUS) and smoldering myeloma (SMM) to malignant multiple …
undetermined significance (MGUS) and smoldering myeloma (SMM) to malignant multiple …
Subclonal evolution in disease progression from MGUS/SMM to multiple myeloma is characterised by clonal stability
Multiple myeloma (MM) is a largely incurable haematological malignancy defined by the
clonal proliferation of malignant plasma cells (PCs) within the bone marrow. Clonal …
clonal proliferation of malignant plasma cells (PCs) within the bone marrow. Clonal …
Molecular basis of clonal evolution in multiple myeloma
Y Furukawa, J Kikuchi - International journal of hematology, 2020 - Springer
The treatment outcome of multiple myeloma (MM) is worse than expected from the average
numbers of non-synonymous mutations, which are roughly correlated with the prognosis of …
numbers of non-synonymous mutations, which are roughly correlated with the prognosis of …
RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma
Multiple myeloma (MM) is a plasma cell cancer with poor survival, characterized by the
expansion of multiple myeloma cells (MMCs) in the bone marrow. Using a microarray-based …
expansion of multiple myeloma cells (MMCs) in the bone marrow. Using a microarray-based …
A multiparameter flow cytometry immunophenotypic algorithm for the identification of newly diagnosed symptomatic myeloma with an MGUS-like signature and long …
B Paiva, MB Vidriales, L Rosiñol, J Martínez-López… - Leukemia, 2013 - nature.com
Achieving complete remission (CR) in multiple myeloma (MM) translates into extended
survival, but two subgroups of patients fall outside this paradigm: cases with unsustained …
survival, but two subgroups of patients fall outside this paradigm: cases with unsustained …
Current strategies for treatment of relapsed/refractory multiple myeloma
JP Laubach, PM Voorhees, H Hassoun… - Expert review of …, 2014 - Taylor & Francis
In spite of significant advances in the management of multiple myeloma (MM), the disease
remains incurable and nearly all patients ultimately relapse and require salvage …
remains incurable and nearly all patients ultimately relapse and require salvage …
Clonal phylogeny and evolution of critical cytogenetic aberrations in multiple myeloma at single-cell level by QM-FISH
Y Yan, X Qin, J Liu, H Fan, W Yan, L Liu, C Du… - Blood …, 2022 - ashpublications.org
Single-cell analysis is of significant importance in delineating the exact phylogeny of the
subclonal population and in discovering subtle diversification. So far, studies of intratumor …
subclonal population and in discovering subtle diversification. So far, studies of intratumor …
DNA repair pathways in human multiple myeloma: role in oncogenesis and potential targets for treatment
C Gourzones-Dmitriev, A Kassambara, S Sahota… - Cell cycle, 2013 - Taylor & Francis
Every day, cells are faced with thousands of DNA lesions, which have to be repaired to
preserve cell survival and function. DNA repair is more or less accurate and could result in …
preserve cell survival and function. DNA repair is more or less accurate and could result in …