The purpose of this review is to demonstrate the critical importance of understanding protein–
excipient interactions as a key step in the rational design of formulations to stabilize and …

Differential scanning calorimetry measures the heat capacity of states and the excess heat
associated with transitions that can be induced by temperature change. The integral of the …

Therapeutic antibodies and antibody derivatives comprise the majority of today's
biotherapeutics. Routine methods to generate novel antibodies, such as immunization and …

Antibody glycosylation is a common post-translational modification and has a critical role in
antibody effector function. The use of glycoengineering to produce antibodies with specific …

The scope of this paper is to review approaches used for forced degradation (synonym,
stress testing) of therapeutic proteins. Forced degradation studies play a central role in the …

Low expression, poor solubility, and polyspecificity are significant obstacles that have
impeded the development of antibodies discovered from in vitro display libraries. Current …

This report describes the design, generation and testing of Ylanthia, a fully synthetic human
Fab antibody library with 1.3 E+ 11 clones. Ylanthia comprises 36 fixed immunoglobulin (Ig) …

The conjugation of hydrophobic cytotoxic agents such as monomethyl auristatin E (MMAE)
to the interchain sulfhydryl groups of monoclonal antibodies (Mabs) through a protease …

Increasing attention has been paid to developability assessment with the understanding that
thorough evaluation of monoclonal antibody lead candidates at an early stage can avoid …

Developability refers to the likelihood that an antibody candidate will become a
manufacturable, safe and efficacious drug. Although the safety and efficacy of a drug …