Epigenetics in Alzheimer's disease

X Gao, Q Chen, H Yao, J Tan, Z Liu, Y Zhou… - Frontiers in aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disease with unknown pathogenesis and
complex pathological manifestations. At present, a large number of studies on targeted …

Normalization methods for the analysis of unbalanced transcriptome data: a review

X Liu, N Li, S Liu, J Wang, N Zhang, X Zheng… - … in bioengineering and …, 2019 - frontiersin.org
Dozens of normalization methods for correcting experimental variation and bias in high-
throughput expression data have been developed during the last two decades. Up to 23 …

[HTML][HTML] Identification of tumor immune infiltration-associated lncRNAs for improving prognosis and immunotherapy response of patients with non-small cell lung …

J Sun, Z Zhang, S Bao, C Yan, P Hou… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Increasing evidence has demonstrated the functional relevance of long non-
coding RNAs (lncRNAs) to immunity regulation and the tumor microenvironment in non …

A review on omics-based biomarkers discovery for Alzheimer's disease from the bioinformatics perspectives: statistical approach vs machine learning approach

MS Tan, PL Cheah, AV Chin, LM Looi… - Computers in biology and …, 2021 - Elsevier
Alzheimer's Disease (AD) is a neurodegenerative disease that affects cognition and is the
most common cause of dementia in the elderly. As the number of elderly individuals …

Advances in transcriptome analysis of human brain aging

S Ham, SJV Lee - Experimental & molecular medicine, 2020 - nature.com
Aging is associated with gradual deterioration of physiological and biochemical functions,
including cognitive decline. Transcriptome profiling of brain samples from individuals of …

Recurrence-associated long non-coding RNA signature for determining the risk of recurrence in patients with colon cancer

M Zhou, L Hu, Z Zhang, N Wu, J Sun, J Su - Molecular Therapy-Nucleic …, 2018 - cell.com
Patients with colon cancer are often faced a high risk of disease recurrence within 5 years of
treatment that is the major cause of cancer mortality. Reliable molecular markers were …

Identification and verification of an immune-related lncRNA signature for predicting the prognosis of patients with bladder cancer

J Wang, C Shen, D Dong, X Zhong, Y Wang… - International …, 2021 - Elsevier
Background Recent studies have revealed the significant roles of immune-related long
noncoding RNAs (lncRNAs) in cancer development and progression. The identification of …

[HTML][HTML] Effect of lncRNA WT1-AS regulating WT1 on oxidative stress injury and apoptosis of neurons in Alzheimer's disease via inhibition of the miR-375/SIX4 axis

Q Wang, X Ge, J Zhang, L Chen - Aging (albany NY), 2020 - ncbi.nlm.nih.gov
Objective: To study the effect of lncRNA WT1-AS on oxidative stress injury (OSI) and
apoptosis of neurons in Alzheimer's disease (AD) and its specific mechanisms related to the …

Depletion of LncRNA NEAT1 rescues mitochondrial dysfunction through NEDD4L-dependent PINK1 degradation in animal models of Alzheimer's disease

Z Huang, J Zhao, W Wang, J Zhou… - Frontiers in cellular …, 2020 - frontiersin.org
Alzheimer's disease (AD) is the most common neurodegenerative disorder and the main
cause of dementia among the elderly worldwide. Unfortunately, the mechanism of AD …

PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer's disease

S Schröder, U Fuchs, V Gisa, T Pena, DM Krüger… - Acta …, 2024 - Springer
Astrocytes provide crucial support for neurons, contributing to synaptogenesis, synaptic
maintenance, and neurotransmitter recycling. Under pathological conditions, deregulation of …