Imidazoquinoline derivatives (IMDs) and related compounds function as synthetic agonists
of Toll-like receptors 7 and 8 (TLR7/8) and one is FDA approved for topical antiviral and skin …

Toll-like receptors (TLRs) are a class of pattern recognition receptors that play a bridging
role in innate immunity and adaptive immunity. The activated TLRs not only induce …

Glioblastoma, the most common and aggressive primary brain tumor type, is considered an
immunologically “cold” tumor with sparse infiltration by adaptive immune cells …

The discovery of the TLRs family and more precisely its functions opened a variety of gates
to modulate immunological host responses. TLRs 7/8 are located in the endosomal …

Background Stereotactic body radiotherapy (SBRT) has been increasingly used as adjuvant
therapy in pancreatic ductal adenocarcinoma (PDAC), and induces immunogenic cell death …

Radiotherapy is one of the most effective and frequently used treatments for a wide range of
cancers. In addition to its direct anti-cancer cytotoxic effects, ionising radiation can augment …

Radiotherapy, a clinically used local treatment modality of cancers, is regarded as a
promising candidate to promote current immunotherapy through initiating an in situ …

Protection of normal tissues against toxic effects of ionizing radiation is a critical issue in
clinical and environmental radiobiology. Investigations in recent decades have suggested …

Toll like receptor (TLR) signaling is involved in activating innate and adaptive immune
responses and plays a critical role in inflammation‐induced diseases such as colorectal …

Simple Summary Radiotherapy is an important component of cancer treatment, given to
around half of all cancer patients. Radiotherapy is known to be very effective at directly …