Sickle cell anemia (SCA) was first described in the Western literature more than 100 years
ago. Elucidation of its molecular basis prompted numerous biochemical and genetic studies …

Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

The pathophysiology of sickle cell disease (SCD) is driven by chronic inflammation fueled by
damage associated molecular patterns (DAMPs). We show that elevated cell-free DNA …

We aimed to identify predictors of outcomes and survival in patients living in 4 major
metropolitan areas who had sickle cell disease (SCD) and COVID-19 to inform best …

Summary Sickle Cell Disease (SCD) is an increasing global health problem and presents
significant challenges to European health care systems. Newborn screening (NBS) for SCD …

Vaso-occlusive episodes (VOEs) are a major concern in patients with sickle cell disease
(SCD). Exposure to systemic corticosteroids has been suspected to increase the occurrence …

Sickle cell disease (SCD) had first been mentioned in the literature a century ago.
Advancement in the molecular basis of the pathophysiology of the disease opens the door …

With increasing survival, cumulative complications of sickle cell disease (SCD), which
develop insidiously over time, are becoming more apparent and common in older patients …

Background Sickle cell disease (SCD) is one of the most common inherited diseases
worldwide. It is associated with lifelong morbidity and a reduced life expectancy …

Gene therapy is an innovative strategy that offers potential cure for patients with sickle cell
disease, and no appropriate donor for transplant consideration. While we await long term …