Marfan syndrome (MFS) is a systemic connective tissue disorder that is inherited in an
autosomal dominant pattern with variable penetrance. While clinically this disease manifests …

The importance of maintaining contractile function in aortic smooth muscle cells (SMCs) is
evident by the fact that heterozygous mutations in the major structural proteins or kinases …

Abstract Aim The “2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic
Disease” provides recommendations to guide clinicians in the diagnosis, genetic evaluation …

Thoracic aortic aneurysms involving the root and/or the ascending aorta enlarge over time
until an acute tear in the intimal layer leads to a highly fatal condition, an acute aortic …

Vascular smooth muscle cells (vSMCs) play a crucial role in both the pathogenesis of
Aneurysms and Dissections of the ascending thoracic aorta (TAAD) in humans and in the …

Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic cause of
myocardial infarction (MI), typically in young women. We undertook a genome-wide …

Thoracic aortic aneurysms that progress to acute aortic dissections are often fatal. Thoracic
aneurysms have been managed with treatment with β-adrenergic blocking agents (β …

Marfan syndrome (MFS) is a rare, autosomal‐dominant, multisystem disorder, presenting
with skeletal, ocular, skin, and cardiovascular symptoms. Significant clinical overlap with …

Inherited thoracic aortopathies denote a group of congenital conditions that predispose to
disease of the thoracic aorta. Aortic wall weakness and abnormal aortic hemodynamic …

Thoracic aortic aneurysm, as occurs in Marfan syndrome, is generally asymptomatic until
dissection or rupture, requiring surgical intervention as the only available treatment. Here …