Carbapenem resistance in Acinetobacter baumannii: laboratory challenges, mechanistic insights and therapeutic strategies

I Abbott, GM Cerqueira, S Bhuiyan… - Expert review of anti …, 2013 - Taylor & Francis
Unprecedented levels of antimicrobial resistance in bacterial isolates have prompted great
concerns globally. In 2012 the WHO released a publication outlining the evolving threat of …

Tigecycline treatment experience against multidrug-resistant Acinetobacter baumannii infections: a systematic review and meta-analysis

W Ni, Y Han, J Zhao, C Wei, J Cui, R Wang… - International Journal of …, 2016 - Elsevier
The role of tigecycline in treating multidrug-resistant Acinetobacter baumannii (MDR-AB)
infections remains controversial. A systematic review and meta-analysis was performed to …

Prolonged infusion antibiotics for suspected gram-negative infections in the ICU: a before-after study

HM Arnold, JM Hollands, LP Skrupky… - Annals of …, 2013 - journals.sagepub.com
BACKGROUND: β-Lactam antibiotics demonstrate time-dependent killing. Prolonged
infusion of these agents is commonly performed to optimize the time the unbound …

In vitro effects of tigecycline in combination with colistin (polymyxin E) and sulbactam against multidrug-resistant Acinetobacter baumannii

W Ni, J Cui, B Liang, Y Cai, N Bai, X Cai… - The Journal of …, 2013 - nature.com
The lack of active antimicrobial agents against multidrug-resistant (MDR) Acinetobacter
baumannii has posed great threat to the public health. Combination therapies with …

Synergistic killing by meropenem and colistin combination of carbapenem-resistant Acinetobacter baumannii isolates from Chinese patients in an in vitro …

X Liu, M Zhao, Y Chen, X Bian, Y Li, J Shi… - International journal of …, 2016 - Elsevier
Carbapenem-resistant Acinetobacter baumannii (CRAB) is an important clinical threat.
Combination therapy that exerts a synergistic effect has become a potential solution to …

Microbiological characteristics and risk factors on prognosis associated with Acinetobacter baumannii bacteremia in general hospital: A single-center retrospective …

Z Wei, S Zhou, Y Zhang, L Zheng, L Zhao… - Frontiers in …, 2022 - frontiersin.org
Objective Acinetobacter baumannii is one of the most important pathogenic bacteria causing
nosocomial infections and has a high mortality rate. Assessment of the microbiological …

[PDF][PDF] Acinetobacter un patógeno actual

J Rada Cuentas - Revista de la Sociedad Boliviana de Pediatría, 2016 - academia.edu
Acinetobacter (inmóvil) es un cocobacilo Gram (-) que durante las tres últimas décadas,
emerge desde un organismo de patogenicidad cuestionable a un agente infeccioso …

Clinical effectiveness of tigecycline in combination therapy against nosocomial pneumonia caused by CR-GNB in intensive care units: a retrospective multi-centre …

KY Yang, CK Peng, CC Sheu, YC Lin, MC Chan… - Journal of Intensive …, 2023 - Springer
Background Tigecycline has in vitro bacteriostatic activity against a broad spectrum of
bacteria, including carbapenem-resistant Gram-negative bacteria (CR-GNB). However, the …

Tracking Cefoperazone/Sulbactam Resistance Development In vivo in A. baumannii Isolated from a Patient with Hospital-Acquired Pneumonia by Whole-Genome …

X Liu, H Zheng, W Zhang, Z Shen, M Zhao… - Frontiers in …, 2016 - frontiersin.org
Cefoperazone/sulbactam has been shown to be efficacious for the treatment of infections
caused by Acinetobacter baumannii; however, the mechanism underlying resistance to this …

A survey on infection management practices in Italian ICUs

M Bassetti, R De Gaudio, T Mazzei, G Morace… - Critical care, 2012 - Springer
Introduction An online survey was conducted to characterize current infection management
practices in Italian intensive care units (ICUs), including the antibacterial and antifungal drug …