After leaving the testis, spermatozoa have not yet acquired the ability to move progressively
and are unable to fertilize oocytes. To become fertilization competent, they must go through …

Male contraception is a very active area of research. Several hormonal agents have entered
clinical trials, while potential non-hormonal targets have been brought to light more recently …

In mammals, motility and fertilizing ability of spermatozoa develop during their passage
through the epididymis. After ejaculation, sperm undergo capacitation and hyperactivation in …

The coordinated and reciprocal action of serine-threonine protein kinases and protein
phosphatases produces transitory phosphorylation, a fundamental regulatory mechanism for …

Spermatozoa have a streamlined shape to swim through the oviduct to fertilize oocytes. To
become svelte spermatozoa, spermatid cytoplasm must be eliminated in several steps …

Background Adenosine deaminase domain containing 2 (ADAD2) is a testis‐specific protein
composed of a double‐stranded RNA binding domain and a non‐catalytic adenosine …

The major post-translational modification in eukaryotes is protein phosphorylation which
mediates responses to signals in a myriad of cellular processes. Not surprisingly, many …

Simple Summary The TSSK1B gene has been demonstrated to play pivotal roles during
spermatogenesis and is associated with male fertility. However, the potential mechanism on …

Transforming growth factor (TGF-β1) is a critical profibrotic mediator in chronic lung disease,
and there are no specific strategies to mitigate its adverse effects. Activation of TGF-β1 …

Male infertility is a global problem affecting a considerable part of the male population.
Current guidelines and practices aimed at diagnosing the cause of this problem still have …