Prefrontal excitatory/inhibitory balance in stress and emotional disorders: evidence for over-inhibition

CE Page, L Coutellier - Neuroscience & Biobehavioral Reviews, 2019 - Elsevier
Chronic stress-induced emotional disorders like anxiety and depression involve imbalances
between the excitatory glutamatergic system and the inhibitory GABAergic system in the …

The dopamine hypothesis of autism spectrum disorder revisited: current status and future prospects

D Pavăl, IV Micluția - Developmental neuroscience, 2021 - karger.com
Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders
characterized by social deficits and stereotyped behaviors. Despite intensive research, its …

Fast-spiking interneurons supply feedforward control of bursting, calcium, and plasticity for efficient learning

SF Owen, JD Berke, AC Kreitzer - Cell, 2018 - cell.com
Fast-spiking interneurons (FSIs) are a prominent class of forebrain GABAergic cells
implicated in two seemingly independent network functions: gain control and network …

The parvalbumin hypothesis of autism spectrum disorder

F Filice, L Janickova, T Henzi, A Bilella… - Frontiers in Cellular …, 2020 - frontiersin.org
The prevalence of autism spectrum disorder (ASD)—a type of neurodevelopmental disorder—
is increasing and is around 2% in North America, Asia, and Europe. Besides the known …

The female Tourette patient: sex differences in Tourette disorder

J Garris, M Quigg - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Tourette Disorder (TD) is a male predominant neurodevelopmental disorder characterized
by tics and frequent psychiatric comorbidities. Girls with TD have later peak symptoms, less …

Antibodies from children with PANDAS bind specifically to striatal cholinergic interneurons and alter their activity

J Xu, RJ Liu, S Fahey, L Frick… - American Journal of …, 2021 - Am Psychiatric Assoc
Objective: Pediatric obsessive-compulsive disorder (OCD) sometimes appears rapidly, even
overnight, often after an infection. Pediatric autoimmune neuropsychiatric disorders …

Cerebellar and striatal implications in autism spectrum disorders: from clinical observations to animal models

M Thabault, V Turpin, A Maisterrena, M Jaber… - International Journal of …, 2022 - mdpi.com
Autism spectrum disorders (ASD) are complex conditions that stem from a combination of
genetic, epigenetic and environmental influences during early pre-and postnatal childhood …

Excessive D1 dopamine receptor activation in the dorsal striatum promotes autistic-like behaviors

Y Lee, H Kim, JE Kim, JY Park, J Choi, JE Lee… - Molecular …, 2018 - Springer
The dopamine system has been characterized in motor function, goal-directed behaviors,
and rewards. Recent studies recognize various dopamine system genes as being …

Disrupted striatal neuron inputs and outputs in Huntington's disease

A Reiner, YP Deng - CNS neuroscience & therapeutics, 2018 - Wiley Online Library
Huntington's disease (HD) is a hereditary progressive neurodegenerative disorder caused
by a CAG repeat expansion in the gene coding for the protein huntingtin, resulting in a …

Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: role of prefrontal cortex projections in cognitive …

M Rapanelli, W Wang, E Hurley, ML Feltri… - Translational …, 2023 - nature.com
Loss-of-function mutations of the gene Cul3 have been identified as a risk factor for autism-
spectrum disorder (ASD), but the pathogenic mechanisms are not well understood …