Working memory is the fundamental function by which we break free from reflexive input-
output reactions to gain control over our own thoughts. It has two types of mechanisms …

A major shift is happening within neurophysiology: a population doctrine is drawing level
with the single-neuron doctrine that has long dominated the field. Population-level ideas …

Persistent activity generated in the PFC during the delay period of working memory tasks
represents information about stimuli held in memory and determines working memory …

Persistent spiking has been thought to underlie working memory (WM). However, virtually all
of the evidence for this comes from studies that averaged spiking across time and across …

Interactions between the prefrontal cortex (PFC) and mediodorsal thalamus are critical for
cognitive flexibility, yet the underlying computations are unknown. To investigate …

For decades, the extent to which visual imagery relies on the same neural mechanisms as
visual perception has been a topic of debate. Here, we review recent neuroimaging studies …

Cortical neurons process information on multiple timescales, and areas important for
working memory (WM) contain neurons capable of integrating information over a long …

Working memory is characterized by neural activity that persists during the retention interval
of delay tasks. Despite the ubiquity of this delay activity across tasks, species and …

The prefrontal cortex maintains working memory information in the presence of distracting
stimuli. It has long been thought that sustained activity in individual neurons or groups of …

Working memory is fundamental to cognition, allowing one to hold information" in mind." A
defining characteristic of working memory is its flexibility: we can hold anything in mind …