Vertebrate Hox genes are critical for the establishment of structures during the development
of the main body axis. Subsequently, they play important roles either in organizing …

Homobox C13 (Hoxc13) is an important transcription factor in hair follicle cycle
development, and its deletion had been found in a variety of animals leading to abnormal …

Background During hair growth, cortical cells emerging from the proliferative follicle bulb
rapidly undergo a differentiation program and synthesize large amounts of hair keratin …

Pure hair and nail ectodermal dysplasia (PHNED) is a congenital disorder characterized by
reduced or absent hair and dystrophic nails. PHNED is caused by pathogenic variants in …

Pure hair and nail ectodermal dysplasia 9 (ECTD‐9) is an autosomal recessive genetic
disease caused by mutation of HOXC13 and is characterized by hypotrichosis and nail …

Hereditary hair loss is characterized by sparse to complete loss of hair from the scalp and
other body parts. It is a clinically diverse and genetically heterogeneous group of inherited …

The human hair follicle (HF) is a complex structure that undergoes continuous cycles of
active growth, regression, and rest throughout life. As a result, the HF has been well …

Loss of function mutations in HOXC13 have been associated with Ectodermal Dysplasia‐9,
Hair/Nail Type (ECTD9) in consanguineous families, characterized by sparse to complete …

Ectodermal dysplasias are a large family of congenital disorders resulting in developmental
defects of at least two structures derived from ectodermal embryologic structure (hair, nails …

The full length of interested genes can be usually cloned by assembling exons or RACE
products through overlap PCR. However, the procedure requires multiple PCR steps, which …