The chemical biology of naphthoquinones and its environmental implications
Y Kumagai, Y Shinkai, T Miura… - Annual review of …, 2012 - annualreviews.org
Quinones are a group of highly reactive organic chemical species that interact with
biological systems to promote inflammatory, anti-inflammatory, and anticancer actions and to …
biological systems to promote inflammatory, anti-inflammatory, and anticancer actions and to …
The effects of connexin phosphorylation on gap junctional communication
PD Lampe, AF Lau - The international journal of biochemistry & cell biology, 2004 - Elsevier
Gap junctions are specialized membrane domains composed of collections of channels that
directly connect neighboring cells providing for the cell-to-cell diffusion of small molecules …
directly connect neighboring cells providing for the cell-to-cell diffusion of small molecules …
[HTML][HTML] 1, 4-naphthoquinones: from oxidative damage to cellular and inter-cellular signaling
Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox
signaling. Here, contributions of redox cycling and alkylating properties of quinones (both …
signaling. Here, contributions of redox cycling and alkylating properties of quinones (both …
[HTML][HTML] Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation
DW Laird - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2005 - Elsevier
Gap junction proteins, connexins, are dynamic polytopic membrane proteins that exhibit
unprecedented short half-lives of only a few hours. Consequently, it is well accepted that in …
unprecedented short half-lives of only a few hours. Consequently, it is well accepted that in …
Anti-cancer activities of 1, 4-naphthoquinones: a QSAR study
RP Verma - Anti-Cancer Agents in Medicinal Chemistry …, 2006 - ingentaconnect.com
Quinone moieties are present in many drugs such as anthracyclines, daunorubicin,
doxorubicin, mitomycin, mitoxantrones and saintopin, which are used clinically in the …
doxorubicin, mitomycin, mitoxantrones and saintopin, which are used clinically in the …
The roles of polyphenols in cancer chemoprevention
KW Lee, HJ Lee - Biofactors, 2006 - Wiley Online Library
Oxidative stress imposed by reactive oxygen species (ROS) plays a crucial role in the
pathophysiology associated with neoplasia, atherosclerosis, and neurodegenerative …
pathophysiology associated with neoplasia, atherosclerosis, and neurodegenerative …
Singlet oxygen-induced signaling effects in mammalian cells
Singlet oxygen, an electronically excited form of molecular oxygen, may be generated
photochemically or in dark reactions in vivo. Singlet oxygen is not only toxic to cells and …
photochemically or in dark reactions in vivo. Singlet oxygen is not only toxic to cells and …
[HTML][HTML] Pharmacology of gap junctions. New pharmacological targets for treatment of arrhythmia, seizure and cancer?
A Salameh, S Dhein - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2005 - Elsevier
Intercellular communication in many organs is maintained via intercellular gap junction
channels composed of connexins, a large protein family with a number of isoforms. This gap …
channels composed of connexins, a large protein family with a number of isoforms. This gap …
Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis
M Shah, JL Stebbins, A Dewing, J Qi… - Pigment cell & …, 2009 - Wiley Online Library
The E3 ubiquitin ligase Siah2 has been implicated in the regulation of the hypoxia response,
as well as in the control of Ras, JNK/p38/NF‐κB signaling pathways. Both Ras/mitogen …
as well as in the control of Ras, JNK/p38/NF‐κB signaling pathways. Both Ras/mitogen …
NQO1 downregulation potentiates menadione-induced endothelial-mesenchymal transition during rosette formation in Fuchs endothelial corneal dystrophy
Fuchs endothelial corneal dystrophy (FECD) is a genetic and oxidative stress disorder of
post-mitotic human corneal endothelial cells (HCEnCs), which normally exhibit hexagonal …
post-mitotic human corneal endothelial cells (HCEnCs), which normally exhibit hexagonal …