Quinones are a group of highly reactive organic chemical species that interact with
biological systems to promote inflammatory, anti-inflammatory, and anticancer actions and to …

Gap junctions are specialized membrane domains composed of collections of channels that
directly connect neighboring cells providing for the cell-to-cell diffusion of small molecules …

Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox
signaling. Here, contributions of redox cycling and alkylating properties of quinones (both …

Gap junction proteins, connexins, are dynamic polytopic membrane proteins that exhibit
unprecedented short half-lives of only a few hours. Consequently, it is well accepted that in …

Quinone moieties are present in many drugs such as anthracyclines, daunorubicin,
doxorubicin, mitomycin, mitoxantrones and saintopin, which are used clinically in the …

Oxidative stress imposed by reactive oxygen species (ROS) plays a crucial role in the
pathophysiology associated with neoplasia, atherosclerosis, and neurodegenerative …

Singlet oxygen, an electronically excited form of molecular oxygen, may be generated
photochemically or in dark reactions in vivo. Singlet oxygen is not only toxic to cells and …

Intercellular communication in many organs is maintained via intercellular gap junction
channels composed of connexins, a large protein family with a number of isoforms. This gap …

The E3 ubiquitin ligase Siah2 has been implicated in the regulation of the hypoxia response,
as well as in the control of Ras, JNK/p38/NF‐κB signaling pathways. Both Ras/mitogen …

Fuchs endothelial corneal dystrophy (FECD) is a genetic and oxidative stress disorder of
post-mitotic human corneal endothelial cells (HCEnCs), which normally exhibit hexagonal …