Abstract Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor
with many important functions in the biology of normal and transformed cells. Its regulation is …

Epithelial tissue homeostasis is closely associated with the self-renewal and differentiation
behaviors of epithelial stem cells (ESCs). p63, a well-known marker of ESCs, is an …

The YAP1/Hippo and p53 pathways are critical protectors of genome integrity in response to
DNA damage. Together, these pathways secure cellular adaptation and maintain overall …

Breast cancer, which is the most common malignant tumor among women worldwide and an
important cause of death in women. The existing prognostic model for patients with breast …

The three p53 family members, p53, p63 and p73, are structurally similar and share many
biochemical activities. Yet, along with their common fundamental role in protecting genomic …

After lung cancer, breast cancer (BC) is the most frequent cause of cancer death among
women, worldwide. Although advances in screening approaches and targeted therapeutic …

Simple Summary Cancer stem cells (CSCs) are a tumor cell population maintaining tumor
growth and promoting tumor relapse if not wholly eradicated during treatment. CSCs are …

Chitosan oligosaccharides have been reported to inhibit various tumors. However, the water-
soluble marine plant oligosaccharide alginate oligosaccharide (AOS) has only rarely been …

Breast cancer is the second leading cause of cancer-related deaths among women, largely
due to the progression of a significant fraction of primary tumours to the metastatic stage …

Breast cancer is a heterogeneous disease. In particular, triple-negative breast cancer
(TNBC) comprises various molecular subgroups with unclear identities and currently has …