Astrocyte roles in traumatic brain injury

JE Burda, AM Bernstein, MV Sofroniew - Experimental neurology, 2016 - Elsevier
Astrocytes sense changes in neural activity and extracellular space composition. In
response, they exert homeostatic mechanisms critical for maintaining neural circuit function …

The mechanics of traumatic brain injury: a review of what we know and what we need to know for reducing its societal burden

DF Meaney, B Morrison… - Journal of …, 2014 - asmedigitalcollection.asme.org
Traumatic brain injury (TBI) is a significant public health problem, on pace to become the
third leading cause of death worldwide by 2020. Moreover, emerging evidence linking …

Revisiting excitotoxicity in traumatic brain injury: from bench to bedside

D Baracaldo-Santamaría, DF Ariza-Salamanca… - Pharmaceutics, 2022 - mdpi.com
Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality.
Consequences vary from mild cognitive impairment to death and, no matter the severity of …

Strain and rate-dependent neuronal injury in a 3D in vitro compression model of traumatic brain injury

E Bar-Kochba, MT Scimone, JB Estrada, C Franck - Scientific reports, 2016 - nature.com
Abstract In the United States over 1.7 million cases of traumatic brain injury are reported
yearly, but predictive correlation of cellular injury to impact tissue strain is still lacking …

Traumatic brain injury, neuroimaging, and neurodegeneration

ED Bigler - Frontiers in human neuroscience, 2013 - frontiersin.org
Depending on severity, traumatic brain injury (TBI) induces immediate neuropathological
effects that in the mildest form may be transient but as severity increases results in neural …

The overlooked aspect of excitotoxicity: Glutamate‐independent excitotoxicity in traumatic brain injuries

J Tehse, C Taghibiglou - European journal of neuroscience, 2019 - Wiley Online Library
Traumatic brain injury (TBI) is a leading major cause of morbidity and mortality in youth and
individuals under 45 year age. A wide variety of cellular and molecular mechanisms have …

[HTML][HTML] Mechanosensation in traumatic brain injury

CE Keating, DK Cullen - Neurobiology of disease, 2021 - Elsevier
Traumatic brain injury (TBI) is distinct from other neurological disorders because it is
induced by a discrete event that applies extreme mechanical forces to the brain. This review …

A porcine model of traumatic brain injury via head rotational acceleration

DK Cullen, JP Harris, KD Browne, JA Wolf… - Injury models of the …, 2016 - Springer
Unique from other brain disorders, traumatic brain injury (TBI) generally results from a
discrete biomechanical event that induces rapid head movement. The large size and high …

[HTML][HTML] Role of microvascular disruption in brain damage from traumatic brain injury

AF Logsdon, BP Lucke-Wold, RC Turner… - Comprehensive …, 2015 - ncbi.nlm.nih.gov
Traumatic brain injury (TBI) is acquired from an external force, which can inflict devastating
effects to the brain vasculature and neighboring neuronal cells. Disruption of vasculature is …

The blood–brain barrier as a target in traumatic brain injury treatment

SC Thal, W Neuhaus - Archives of medical research, 2014 - Elsevier
Traumatic brain injury (TBI) is one of the most frequent causes of death in the young
population. Several clinical trials have unsuccessfully focused on direct neuroprotective …