Advanced strategies for CRISPR/Cas9 delivery and applications in gene editing, therapy, and cancer detection using nanoparticles and nanocarriers
ARK Hii, X Qi, Z Wu - Journal of Materials Chemistry B, 2024 - pubs.rsc.org
Cancer remains one of the deadliest diseases, and is characterised by the uncontrolled
growth of modified human cells. Unlike infectious diseases, cancer does not originate from …
growth of modified human cells. Unlike infectious diseases, cancer does not originate from …
Vision on Synthetic and Medicinal Facets of 1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine Scaffold
The present review article strives to compile the latest synthetic approaches for the synthesis
of triazolothiadiazine and its derivatives, along with their diverse pharmacological activities …
of triazolothiadiazine and its derivatives, along with their diverse pharmacological activities …
Indenyl-thiazole and indenyl-formazan derivatives: Synthesis, anticancer screening studies, molecular-docking, and pharmacokinetic/molin-spiration properties
GH Alfaifi, TA Farghaly, MH Abdellattif - Plos one, 2023 - journals.plos.org
Two new series of thiazole and formazan linked to 5-Bromo-indan were synthesized, and
their structures were assured based on all possible analytical techniques. The size of the …
their structures were assured based on all possible analytical techniques. The size of the …
[HTML][HTML] Synthesis, anticancer activity, and molecular docking of new pyrazolo [1, 5-a] pyrimidine derivatives
A Hossan, AF Alrefaei, HA Katouah, A Bayazeed… - Journal of Saudi …, 2023 - Elsevier
The reaction of 3-aminopyrzoles with dimethylamino-acrylonitrile derivatives was utilized for
the production of new functionalized pyrazolopyrimidine compounds 4a-c and 6a-c. The …
the production of new functionalized pyrazolopyrimidine compounds 4a-c and 6a-c. The …
Design and Synthesis of New bis-oxindole and Spiro (triazole-oxindole) as CDK4 Inhibitors with Potent Anti-breast Cancer Activity
TA Farghaly, RA Pashameah, A Bayazeed… - Medicinal …, 2024 - ingentaconnect.com
Background: Since CDKs have been demonstrated to be overexpressed in a wide spectrum
of human malignancies, their inhibition has been cited as an effective technique for …
of human malignancies, their inhibition has been cited as an effective technique for …
Affinity character analysis of magnolol and honokiol based on stepwise frontal analysis coupled with cell membrane chromatography
X He, M Zhang, F Wei, S Wang - Journal of Chromatography B, 2023 - Elsevier
Magnolol and honokiol have been reported to exhibit anti-cancer activity. However, few
studies are in relation to the interaction of magnolol/honokiol with vascular endothelial …
studies are in relation to the interaction of magnolol/honokiol with vascular endothelial …
Synthesis of tricyclic and tetracyclic benzo [6, 7] cycloheptane derivatives linked morpholine moiety as CDK2 inhibitors
TA Farghaly, EMH Abbas, MA Al‐Sheikh… - Drug Development …, 2023 - Wiley Online Library
With the aim of developing cyclin‐dependent kinase 2 (CDK2) inhibitors with strong
antibreast cancer efficacy, new tricyclic and tetracyclic benzo [6, 7] cycloheptane derivatives …
antibreast cancer efficacy, new tricyclic and tetracyclic benzo [6, 7] cycloheptane derivatives …
Elucidating activation and deactivation dynamics of VEGFR-2 transmembrane domain with coarse-grained molecular dynamics simulations
YJ Go, M Kalathingal, YM Rhee - PloS one, 2023 - journals.plos.org
The vascular endothelial growth factor receptor 2 (VEGFR-2) is a member of receptor
tyrosine kinases (RTKs) and is a dimeric membrane protein that functions as a primary …
tyrosine kinases (RTKs) and is a dimeric membrane protein that functions as a primary …
Thiazole–A promising scaffold for antituberculosis agents and structure–activity relationships studies
X Zhao, J Di, D Luo, R Verma, SK Verma, S Verma… - Bioorganic …, 2024 - Elsevier
Research on thiazole derivatives has been a popular topic in medicine and one of the most
active fields in heterocyclic chemistry. Pharmacological and industrial researchers have …
active fields in heterocyclic chemistry. Pharmacological and industrial researchers have …
Synthesis of novel series of heterocyclic compounds having two azoles against Methicillin-sensitive Staphylococcus aureus
A Alamri, A Alafnan, B Huwaimel, AS Abouzied… - Journal of Molecular …, 2023 - Elsevier
In the pharmaceutical industry, both thiazole-linked-thiadiazoles and dithiazoles are known
for their numerous biological activities in the treatment of many diseases. Thiazole-linked …
for their numerous biological activities in the treatment of many diseases. Thiazole-linked …