Human epidermal growth factor receptor 2, HER2, is a commonly over-expressed tyrosine
kinase receptor found in many types of carcinoma. Despite that there are several HER2 …

Abstract Prion diseases (eg Creutzfeldt-Jakob disease (CJD), variant CJD (vCJD),
Gerstmann-Sträussler-Scheinker syndrome (GSS), Fatal Familial Insomnia (FFI) and Kuru in …

Drug resistant mutations have severely restricted the success of HIV therapy. These
mutations frequently involve the aspartic protease encoded by the virus. Knowledge of the …

The C-terminus of Protein Tyrosine Phosphatase 1B (PTP1B) includes an α-helix (α7), which
forms an allosteric binding site 20 Å away from the active site. This helix is specific to PTP1B …

Peroxisome proliferator-activated receptors α, δ, and γ are a collection of ligand-activated
transcription factors crucial in lipid and glucose homeostasis. The involvement of these …

Human epidermal growth factor receptor 2 (HER2) is a member of the human epidermal
growth factor receptor kinases (other members include EGFR or HER1, HER3, and HER4) …

Computational prediction of RNA tertiary structures is a significant challenge, especially for
longer RNA and pseudoknots. At present it is still difficult to do this by pure all-atom …

Point mutations in the human prion protein gene, leading to amino acid substitutions in the
human prion protein contribute to conversion of PrPC to PrPSc and amyloid formation …

Phosphodiesterase superfamily is the key regulator of 3′, 5′-cyclic guanosine
monophosphate (cGMP) decomposition in human body. Phosphodiesterase-5 (PDE-5) …

Pseudomonas aeruginosa is the major cause of morbidity and mortality in patients with
cystic fibrosis. The high level of intrinsic and acquired antibiotic resistance of P. aeruginosa …