Incidences of altered development and neoplasia of male reproductive organs have
increased during the last 50 years, as shown by epidemiological data. These data are …

Dynamic reciprocity (DR) refers to the ongoing, bidirectional interaction between cells and
their microenvironment, specifically the extracellular matrix (ECM). The continuous …

Organoids have certain cellular composition and physiological features in common with real
organs, making them promising models of organ formation, function, and diseases …

The standard viewpoint that cancer is a genetic disease is often stated as a fact rather than a
theory. By not acknowledging that it is a theory, namely the Somatic Mutation Theory (SMT) …

Lacking an operational theory to explain the organization and behaviour of matter in
unicellular and multicellular organisms hinders progress in biology. Such a theory should …

Insoluble cues from a cell's surrounding microenvironment have increasingly been shown to
be important regulators of cell behavior. The microarchitecture of biomaterials used for 3D …

Fiber-like structures are prevalent in biological tissues, yet quantitative approaches to
assess their three-dimensional (3D) organization are lacking. We develop 3D directional …

In multicellular organisms, relations among parts and between parts and the whole are
contextual and interdependent. These organisms and their cells are ontogenetically linked …

Defining fiber orientation at each voxel within a 3D biomedical image stack is potentially
useful for a variety of applications, including cancer, wound healing and tissue regeneration …

The salivary gland is a complex, secretory tissue that produces saliva and maintains oral
homeostasis. Radiation induced salivary gland atrophy, manifested as “dry mouth” or …