MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression after
transcription. miRNAs are present in transcriptionally quiescent full-grown oocytes and …

The shift from maternal to embryonic control is a critical developmental milestone in
preimplantation development. Widespread transcriptomic and epigenetic remodeling …

Background The transcriptional changes around zygotic genome activation (ZGA) in
preimplantation embryos are critical for studying mechanisms of embryonic developmental …

How histone modifications regulate changes in gene expression during preimplantation
development in any species remains poorly understood. Using CUT&Tag to overcome …

Maternal mRNA clearance is critical for the early embryo development, which is under the
tight control of RNA N6-methyladenosine (m6A). However, little information is known …

The molecular consequences of the metabolic stress caused by milk production of dairy
cows in the early embryo are largely unknown. The objective was to determine the impact of …

Supporting healthy pregnancy outcomes requires a comprehensive understanding of the
molecular and cellular programs of peri-implantation development, when most pregnancy …

Graphical Abstract Abstract The transition of maternal to zygotic gene expression regulation
is critical for human preimplantation embryo development. In recent years, single-cell RNA …

Background Although, oocytes from prepubertal donors are known to be less
developmentally competent than those from adult donors it does not restrain their ability to …

Haploid embryos have contributed significantly to our understanding of the role of parental
genomes in development and can be applied to important biotechnology for human and …