Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases

LJ Spielman, DL Gibson, A Klegeris - Neurochemistry international, 2018 - Elsevier
The number of bacterial cells living within the human body is approximately equal to, or
greater than, the total number of human cells. This dynamic population of microorganisms …

Vagus nerve and underlying impact on the gut microbiota-brain axis in behavior and neurodegenerative diseases

Y Han, B Wang, H Gao, C He, R Hua… - Journal of …, 2022 - Taylor & Francis
The gut microbiota is the most abundant and diverse microbiota in the human body and the
vagus nerve is the most widely distributed and complex nerve in the body, both of them are …

Modeling psychomotor retardation using iPSCs from MCT8-deficient patients indicates a prominent role for the blood-brain barrier

GD Vatine, A Al-Ahmad, BK Barriga, S Svendsen… - Cell stem cell, 2017 - cell.com
Inactivating mutations in the thyroid hormone (TH) transporter Monocarboxylate transporter
8 (MCT8) cause severe psychomotor retardation in children. Animal models do not reflect …

Immunity in amyotrophic lateral sclerosis: Blurred lines between excessive inflammation and inefficient immune responses

LC Béland, A Markovinovic, H Jakovac… - Brain …, 2020 - academic.oup.com
Despite wide genetic, environmental and clinical heterogeneity in amyotrophic lateral
sclerosis, a rapidly fatal neurodegenerative disease targeting motoneurons …

Activated Microglia Disrupt the Blood-Brain Barrier and Induce Chemokines and Cytokines in a Rat in vitro Model

Y Shigemoto-Mogami, K Hoshikawa… - Frontiers in cellular …, 2018 - frontiersin.org
Severe neuroinflammation is associated with blood brain barrier (BBB) disruption in CNS
diseases. Although microglial activation and the subsequent changes in cytokine/chemokine …

The role of short-chain fatty acids in microbiota–gut–brain cross-talk with a focus on amyotrophic lateral sclerosis: a systematic review

A Moțățăianu, G Șerban, S Andone - International Journal of Molecular …, 2023 - mdpi.com
Amyotrophic lateral sclerosis is a devastating neurodegenerative disease characterized by
the gradual loss of motor neurons in the brain and spinal cord, leading to progressive motor …

Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact

F De Marchi, I Munitic, A Amedei, JD Berry… - Neuroscience & …, 2021 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a debilitating and rapidly fatal neurodegenerative
disease. Despite decades of research and many new insights into disease biology over the …

Breached barriers: a scoping review of blood-central nervous system barrier pathology in amyotrophic lateral sclerosis

A Mirian, A Moszczynski, S Soleimani… - Frontiers in Cellular …, 2022 - frontiersin.org
Introduction Recent studies have implicated changes in the blood-central nervous system
barriers (BCNSB) in amyotrophic lateral sclerosis (ALS). The objective of this scoping review …

Current advancement of immunomodulatory drugs as potential pharmacotherapies for autoimmunity based neurological diseases

H Ashraf, P Solla, LA Sechi - Pharmaceuticals, 2022 - mdpi.com
Dramatic advancement has been made in recent decades to understand the basis of
autoimmunity-mediated neurological diseases. These diseases create a strong influence on …

[HTML][HTML] Glial smog: Interplay between air pollution and astrocyte-microglia interactions

M Gómez-Budia, H Konttinen, L Saveleva… - Neurochemistry …, 2020 - Elsevier
Every second we inhale a danger in the air; many particles in the atmosphere can influence
our lives. Outdoor air pollution, especially particulate matter is the largest environmental risk …