Reactive oxygen species (ROS) represent a group of high reactive molecules with dualistic
natures since they can induce cytotoxicity or regulate cellular physiology. Among the ROS …

Within the last twenty years the view on reactive oxygen species (ROS) has changed; they
are no longer only considered to be harmful but also necessary for cellular communication …

Osteopontin (OPN) is a multifunctional cytokine that can impact cancer progression.
Therefore, it is crucial to determine the key factors involved in the biological role of OPN for …

The NADPH oxidase (NOX) family of enzymes produces ROS as their sole function and is
becoming recognized as key modulators of signal transduction pathways with a …

Significance: The primary function of NADPH oxidases (NOX1–5 and dual oxidases
DUOX1/2) is to produce reactive oxygen species (ROS). If inadequately regulated, NOX …

Our previous studies have confirmed that NADPH oxidase 4 (NOX4) is abundantly
expressed in non-small cell lung cancer (NSCLC) and contributes to cancer progression …

This short review article summarizes what is known clinically and biochemically about the
seven human NADPH oxidases. Emphasis is put on the connection between mutations in …

The Transforming Growth Factor-beta (TGF-β) pathway plays essential roles in liver
development and homeostasis and become a relevant factor involved in different liver …

Significance: Flavonoids can interact with multiple molecular targets to elicit their cellular
effects, leading to changes in signal transduction, gene expression, and/or metabolism …

Abstract NADPH oxidase 1 (NOX1) plays a key role in tumorigenesis and metastasis
through generating reactive oxygen species (ROS), an important intracellular signaling …