Background No study has gathered evidence from all randomized clinical trials (RCT s) with
anti‐inflammatory drugs measuring antidepressant effects including a detailed assessment …

Bipolar disorder (BD) is strongly associated with immune dysfunction. Replicated
epidemiological studies have demonstrated that BD has high rates of inflammatory medical …

This study aimed to investigate the role of baseline levels of peripheral inflammation when
testing the efficacy of antidepressant augmentation with minocycline in patients with …

Microglia are activated in many neurological diseases and have been suggested to play an
important role in the development of affective disorders including major depression. To …

Importance Insufficient treatment response and resulting chronicity constitute a major
problem in depressive disorders. Remission rates range as low as 15% to 40% and …

Objectives To systematically review the efficacy and safety of anti-inflammatory agents for
patients with major depressive disorders. Methods We searched the literature to identify …

Depression, one of the most common mental health disorders, is among the leading causes
of health-related disability worldwide. Although antidepressant treatment has been available …

Background Minocycline has been identified as a potential novel treatment for depression.
The objective of the current review is to determine the overall antidepressant efficacy and …

Neuroinflammation with excess microglial activation and synaptic dysfunction are early
symptoms of most neurological diseases. However, how microglia-associated …

Background: Evidence suggests that anti-inflammatory medication may be effective in the
treatment of depressive symptoms. In this study, we aimed to investigate whether …