Lifelong indices of maladaptive behavior or illness often stem from early physiological
aberrations during periods of dynamic development. This is especially true when …

Failure to appropriately predict and titrate reactivity to threat is a core feature of fear and
anxiety-related disorders and is common following early life adversity (ELA). A population of …

Antisense oligonucleotides (ASOs) are promising therapeutics for intractable central
nervous system (CNS) diseases. For this clinical application, neurotoxicity is one of the …

Exposure to intermittent repeated social defeat (IRSD) increases the vulnerability of mice to
the rewarding effects of cocaine in the conditioned place preference (CPP) paradigm …

Gender is considered as a pivotal determinant of mental health. Indeed, several psychiatric
disorders such as anxiety and depression are more common and persistent in women than …

Abstract Brain and Muscle Arnt-like Protein 1 (BMAL1) is an essential component of the
molecular clock underlying circadian rhythmicity. Its function has been recently associated …

Substance use disorders are more prevalent in schizophrenia, but the causal links between
both conditions remain unclear. Maternal immune activation (MIA) is associated with …

Rationale The combination of several risk factors (sex, a prior underlying psychiatric
condition, or early drug initiation) could induce the emergence of negative affect during …

The endocannabinoid system is prominently implicated in the control of cocaine
reinforcement due to its relevant role in synaptic plasticity and neurotransmitter modulation …

Abstract Background and Purpose New psychoactive substances such as N‐ethylpentylone
(NEP) are continuously emerging in the illicit drug market, and knowledge of their effects …