Understanding the FLASH effect to unravel the potential of ultra-high dose rate irradiation

H Kacem, A Almeida, N Cherbuin… - International journal of …, 2022 - Taylor & Francis
A reemergence of research implementing radiation delivery at ultra-high dose rates
(UHDRs) has triggered intense interest in the radiation sciences and has opened a new field …

FLASH: New intersection of physics, chemistry, biology, and cancer medicine

MC Vozenin, BW Loo Jr, S Tantawi, PG Maxim… - Reviews of Modern …, 2024 - APS
Ultrahigh dose rate, FLASH radiotherapy has emerged as one of the most promising
innovations over the past decade in the field of radiation oncology, with the potential to …

Monte Carlo simulation of chemistry following radiolysis with TOPAS-nBio

J Ramos-Méndez, J Perl, J Schuemann… - Physics in Medicine …, 2018 - iopscience.iop.org
Simulation of water radiolysis and the subsequent chemistry provides important information
on the effect of ionizing radiation on biological material. The Geant4 Monte Carlo toolkit has …

[HTML][HTML] Comparing radiolytic production of H2O2 and development of Zebrafish embryos after ultra high dose rate exposure with electron and transmission proton …

H Kacem, S Psoroulas, G Boivin, M Folkerts… - Radiotherapy and …, 2022 - Elsevier
The physico-chemical and biological response to conventional and UHDR electron and
proton beams was investigated, along with conventional photons. The temporal structure …

Time-and space-resolved Monte Carlo study of water radiolysis for photon, electron and ion irradiation

MS Kreipl, W Friedland, HG Paretzke - Radiation and environmental …, 2009 - Springer
Time-dependent yields of the most important products of water radiolysis e _ aq^-,• OH, H•,
H 3 O+, H 2, OH− and H 2 O 2 have been calculated for 60 Co-photons, electrons, protons …

Independent reaction times method in Geant4‐DNA: Implementation and performance

J Ramos‐Méndez, W Shin, M Karamitros… - Medical …, 2020 - Wiley Online Library
Purpose The simulation of individual particle tracks and the chemical stage following water
radiolysis in biological tissue is an effective means of improving our knowledge of the …

Geant4-DNA simulation of the pre-chemical stage of water radiolysis and its impact on initial radiochemical yields

WG Shin, J Ramos-Mendez, NH Tran, S Okada… - Physica Medica, 2021 - Elsevier
This paper demonstrates the impact of the pre-chemical stage, especially the dissociation
scheme and the associated probabilities, on water radiolysis simulation using the Geant4 …

Evaluation of the influence of physical and chemical parameters on water radiolysis simulations under MeV electron irradiation using Geant4-DNA

WG Shin, J Ramos-Mendez, B Faddegon… - Journal of Applied …, 2019 - pubs.aip.org
This paper presents the influence of electron elastic scattering models, electron
thermalization models, and chemical parameters on Geant4-DNA simulations of liquid water …

[HTML][HTML] Importance of radiolytic reactions during high-LET irradiation modalities: LET effect, role of O2 and radiosensitization by nanoparticles

G Baldacchino, E Brun, I Denden, S Bouhadoun… - Cancer …, 2019 - Springer
This article reviews radiation chemistry processes induced by high-linear energy transfer
(LET) radiation. The first part gives a short historical introduction and defines the essential …

Synthesis of hydrogen peroxide in water ice by ion irradiation

MJ Loeffler, U Raut, RA Vidal, RA Baragiola… - Icarus, 2006 - Elsevier
We present infrared absorption studies on the effects of 50–100 keV Ar+ and 100 keV H+ ion
irradiation of water ice films at 20–120 K. The results support the view that energetic ions …