All causes of renal allograft injury, when severe and/or sustained, can result in chronic
histological damage of which interstitial fibrosis and tubular atrophy are dominant features …

The natural history of renal allograft damage has been characterized in serial protocol
biopsies. The prevalence of subclinical rejection (SCR) is maximal during the first months …

Chronic allograft nephropathy (CAN) in protocol biopsies is associated with graft loss while
the association between subclinical rejection (SCR) and outcome has yielded contradictory …

We conducted a randomized, multicenter study to determine whether treatment of subclinical
rejection with increased corticosteroids resulted in beneficial outcomes in renal transplant …

The contributions of donor kidney quality (partially determined by donor age), allograft
rejection, and calcineurin inhibitor nephrotoxicity on the progression of histologic damage of …

Background. Subclinical rejection and interstitial fibrosis and tubular atrophy (IF/TA) in
protocol biopsies are associated with outcome. We study the relationship between histologic …

Background. We report the 5-year outcomes from a randomized prospective trial in primary
adult renal allograft recipients, designed to evaluate calcineurin inhibitor (CNI)-free …

The diagnosis of acute T cell-mediated rejection (aTCMR) after kidney transplantation has
considerable relevance for research purposes. Its definition is primarily based on …

We previously established a six-gene–based blood score associated with operational
tolerance in kidney transplantation which was decreased in patients developing anti-HLA …

Tacrolimus has a narrow therapeutic window and is characterized by a large inter‐individual
variability in bioavailability. The impact of tacrolimus exposure on subclinical evolution of …