[HTML][HTML] Cell fate decisions, transcription factors and signaling during early retinal development
R Diacou, P Nandigrami, A Fiser, W Liu… - Progress in retinal and …, 2022 - Elsevier
The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …
The evolution of transcriptional regulation in eukaryotes
Gene expression is central to the genotype-phenotype relationship in all organisms, and it is
an important component of the genetic basis for evolutionary change in diverse aspects of …
an important component of the genetic basis for evolutionary change in diverse aspects of …
The probability of duplicate gene preservation by subfunctionalization
M Lynch, A Force - Genetics, 2000 - academic.oup.com
It has often been argued that gene-duplication events are most commonly followed by a
mutational event that silences one member of the pair, while on rare occasions both …
mutational event that silences one member of the pair, while on rare occasions both …
The Spectrum of PAX6 Mutations and Genotype-Phenotype Correlations in the Eye
The transcription factor PAX6 is essential in ocular development in vertebrates, being
considered the master regulator of the eye. During eye development, it is essential for the …
considered the master regulator of the eye. During eye development, it is essential for the …
[HTML][HTML] Congenital aniridia beyond black eyes: from phenotype and novel genetic mechanisms to innovative therapeutic approaches
Congenital PAX6-aniridia, initially characterized by the absence of the iris, has progressively
been shown to be associated with other developmental ocular abnormalities and systemic …
been shown to be associated with other developmental ocular abnormalities and systemic …
Early eye development in vertebrates
RL Chow, RA Lang - Annual review of cell and developmental …, 2001 - annualreviews.org
▪ Abstract This review provides a synthesis that combines data from classical
experimentation and recent advances in our understanding of early eye development …
experimentation and recent advances in our understanding of early eye development …
Pax 6: mastering eye morphogenesis and eye evolution
WJ Gehring, K Ikeo - Trends in genetics, 1999 - cell.com
Pax 6 genes from various animal phyla are capable of inducing ectopic eye development,
indicating that Pax 6 is a master control gene for eye morphogenesis. It is proposed that the …
indicating that Pax 6 is a master control gene for eye morphogenesis. It is proposed that the …
Structure, function and evolution of CpG island promoters
F Antequera - Cellular and Molecular Life Sciences CMLS, 2003 - Springer
Mammalian promoters belong to two different categories in terms of base composition and
DNA methylation. In humans and mice, approximately 60% of all promoters colocalize with …
DNA methylation. In humans and mice, approximately 60% of all promoters colocalize with …
Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
R Ashery-Padan, T Marquardt, X Zhou… - Genes & …, 2000 - genesdev.cshlp.org
The Pax6 transcription factor plays a key role in ocular development of vertebrates and
invertebrates. Homozygosity of the Pax6 null mutation in human and mice results in arrest of …
invertebrates. Homozygosity of the Pax6 null mutation in human and mice results in arrest of …
Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells
The classical view of neural plate development held that it arises from the ectoderm, after its
separation from the mesodermal and endodermal lineages. However, recent cell-lineage …
separation from the mesodermal and endodermal lineages. However, recent cell-lineage …