Lysophospholipids, exemplified by lysophosphatidic acid (LPA) and sphingosine 1-
phosphate (S1P), are produced by the metabolism and perturbation of biological …

Gastric cancer is globally the fourth leading cause of cancer-related deaths. Patients with
diffuse-type gastric cancer (DGC) particularly have a poor prognosis that only marginally …

Targeted and specific induction of cell death in an individual or groups of cells hold the
potential for new insights into the response of tissues or organisms to different forms of …

The gut barrier acts as a first line of defense in the body, and plays a vital role in nutrition
and immunoregulation. A layer of epithelial cells bound together via intercellular junction …

Cell proliferation is central to epithelial tissue development, repair, and homeostasis. During
cell division, small RhoGTPases control both actomyosin dynamics and cell-cell junction …

Geometry is a fundamental attribute of biological systems, and it underlies cell and tissue
dynamics. Cell geometry controls cell-cycle progression and mitosis and thus modulates …

Respiratory syncytial virus (RSV) selectively targets ciliated cells in human bronchial
epithelium and can cause bronchiolitis and pneumonia, mostly in infants. To identify …

In metazoans, living cells achieve capabilities beyond individual cell functionality by
assembling into multicellular tissue structures. These higher-order structures represent …

Apoptosis is traditionally considered to be an immunologically silent form of cell death.
Multiple mechanisms exist to ensure that apoptosis does not stimulate the immune system to …

For the maintenance of epithelial homeostasis, various aberrant or dysfunctional cells are
actively eliminated from epithelial layers. This cell extrusion process mainly falls into two …